53159-75-4

Usage

Uses

Used in Agricultural Industry:
Fluotriazole is used as a fungicide for controlling various crop diseases. It functions by inhibiting the production of ergosterol, a vital component of fungal cell membranes, which results in cell death and prevents the spread of fungal infections. Its effectiveness against a broad spectrum of fungal pathogens makes it a valuable asset in crop protection.
However, it is crucial to handle and apply fluotriazole with care due to its toxic and potentially harmful properties, ensuring the safety of both the environment and the individuals involved in its application.

Upstream product

• 13908-32-2 1-(2-chloroethyl)-3-(4-fluorophenyl)urea 
• 371-40-4 4-fluoroaniline 
• 120-93-4 imidazolidone 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1146944-21-9 1-(4-fluorophenyl)-3-(octan-2-yl)imidazolidin-2-one 
• 868601-09-6 [3-f3-(4-fluoro-phenyl)-2-oxo-imidazolidin-1-yl]-1,1-dimethyl-isopropylcarbamic acid tert-butyl ester 
• 1225208-27-4 C₁₇H₂₄FN₃O 
• 1596360-60-9 methyl 6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxylate 
• 1596360-40-5 N-[(1S)-5-amino-1-cyano-pentyl]-6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxamide 
• 1596360-83-6 9H-fluoren-9-ylmethyl N-[(5S)-5-cyano-5-[[6-[[3-(4-fluorophenyl)-2-oxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carbonyl]amino]pentyl]carbamate 
• 1195779-92-0 N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-2-(2,6-dichlorophenyl)-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide 
• 1000851-01-3 3-(4-fluorophenyl)-2-oxoimidazolidine-1-carbothioyl chloride 

Relevant academic research and scientific papers

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin

In the development of plasmin inhibitors, a novel chemotype, pyrrolopyrimidine scaffold possessing two motifs, a hydantoin-containing P4 moiety and a warhead-containing P1 moiety, is uncovered. A unique feature of the new line of the plasmin inhibitors is

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS

Substituted heteroaryl nitrile derivatives of Formula (I) processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.

New substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with α2-adrenoceptor antagonist activity

The emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at α2-adrenoceptors. A series of substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives bearing an amide, urea, or imidazolidinone moiety was studied. Some members of this series of compounds proved to be potent α2-adrenoceptor antagonists with good selectivity versus α1-adrenergic and D2-dopamine receptors. Particular emphasis is given to compound 33g which displays potent α2-adrenoceptor binding affinity in vitro and central effects in vivo following oral administration.