53164-04-8

Basic information

• Product Name: <1-(4-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy>essigsaeurebenzylester
• Synonyms: <1-(4-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy>essigsaeurebenzylester
• CAS NO: 53164-04-8
• Molecular Weight: 505.955
• Mol File: 53164-04-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: <1-(4-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy>essigsaeurebenzylester(CAS DataBase Reference)
• NIST Chemistry Reference: <1-(4-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy>essigsaeurebenzylester(53164-04-8)
• EPA Substance Registry System: <1-(4-Chlorbenzoyl)-5-methoxy-2-methylindol-3-acetoxy>essigsaeurebenzylester(53164-04-8)

Safety Data

• Hazardous Substances Data: 53164-04-8(Hazardous Substances Data)

Upstream product

• 30379-58-9 benzyl glycolate 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 5437-45-6 Benzyl bromoacetate 
• 123-76-2 levulinic acid 
• 76812-84-5 Laevulinoyloxyessigsaeurebenzylester-N¹-(4-chlorbenzoyl)-N¹-(4-methoxyphenyl)-hydrazon 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 53164-03-7 Laevulinoyloxyessigsaeurebenzylester 

Downstream Products

• 53164-05-9 acemetacin 

Relevant articles and documents

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats

The brain uptake of solutes is efficiently governed by the blood-brain barrier (BBB). The BBB expresses a number of carrier-mediated transport mechanisms, and new knowledge of these BBB transporters can be used in the rational targeted delivery of drug molecules for active transport. One attractive approach is to conjugate an endogenous transporter substrate to the active drug molecule to utilize the prodrug approach. In the present study, ketoprofen and indomethacin were conjugated with glucose and the brain uptake mechanism of the prodrugs was determined with the in situ rat brain perfusion technique. Two of the prodrugs were able to significantly inhibit the uptake of glucose transporter (GluT1)-mediated uptake of glucose, thereby demonstrating affinity to the transporter. Furthermore, the prodrugs were able to cross the BBB in a temperature-dependent manner, suggesting that the brain uptake of the prodrugs is carrier-mediated.