90096-39-2

Usage

Chemical structure

A piperazine ring with a benzhydryl group and a 3-hydroxypropyl group attached.

Usage in pharmaceutical industry

Serves as an intermediate in the synthesis of potential drug candidates.

Potential therapeutic applications

Anti-inflammatory and analgesic properties, as well as possible use in the treatment of central nervous system disorders.

Versatility

Shown promise in various pharmacological applications.

Upstream product

• 5317-32-8 3-(1-piperazinyl)-1-propanol 
• 776-74-9 Bromodiphenylmethane 
• 841-77-0 diphenylmethylpiperazine 
• 107-18-6 allyl alcohol 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 90096-24-5 acetoacetic acid 3-(4-diphenylmethylpiperadyl-1-yl) propylester 
• 75591-22-9 1-(3-chloropropyl)-4-(diphenylmethyl)piperazine 
• 93358-79-3 2-[3-(4-benzhydryl-piperazin-1-yl)-propyl]-isoindole-1,3-dione 
• 50971-75-0 3-[4-(diphenylmethyl)piperazin-1-yl]propylamine 
• 263401-69-0 6-[3-[4-(Diphenylmethyl)-1-piperazinyl]propoxy][1,2,4]triazolo[4,3-b]pyridazine 
• 90095-89-9 4-(3-Chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[3-(4-benzhydryl-piperazin-1-yl)-propyl] ester 5-methyl ester; hydrochloride 

Relevant academic research and scientific papers

Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis

Controlling the selectivity in a hydroamination reaction is an extremely challenging yet highly desirable task for the diversification of amines. In this article, a selective formal anti-Markovnikov hydroamination of allyl alcohols is presented. It enables the versatile synthesis of valuable γ-amino alcohol building blocks. A phosphine-free Earth's abundant manganese(I) complex catalyzed the reaction under hydrogen-borrowing conditions. A vast range of aliphatic, aromatic amines, drug molecules, and natural product derivatives underwent successful hydroamination with primary and secondary allylic alcohols with excellent functional group tolerance (57 examples). The catalysis could be performed on a gram scale and has been applied for the synthesis of drug molecules. The mechanistic studies revealed the metal-ligand bifunctionality as well as hemilability of the ligand backbone as the key design principle for the success of this catalysis.

Hydrogenated acridine derivative and its application

The invention relates to the field of chemical synthesis, and particularly relates to a compound with the general formula being Y-L-X and an application of the compound serving as a calcium channel blocking agent or/and an acetylcholinesterase inhibitor. The compound with the general formula being Y-L-X can be used for adjusting calcium homeostasis and treating cardiovascular diseases, stroke or dementia.

Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-dicarboxylic acids

Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula STR1 wherein R1, R2 and R3 are the same or different and each is alkyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; R4 and R5 are the same or different and each is hydrogen, halogen, nitro, trifluoromethyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio; R6 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl or a pyridyl; X is oxygen, sulfur, vinylene, azomethine or a group of the formula STR2 A is alkylene; Ar is aryl or a pyridyl; m is an integer of 1 to 3; n is an integer of 0 to 2.