5317-95-3

Basic information

• Product Name: N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide
• Synonyms: N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide;4'-(BroMoacetyl)-p-toluenesulfonanilide
• CAS NO: 5317-95-3
• Molecular Formula: C₁₅H₁₄BrNO₃S
• Molecular Weight: 368.24556
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 5317-95-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide(5317-95-3)
• EPA Substance Registry System: N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide(5317-95-3)

Safety Data

• Hazardous Substances Data: 5317-95-3(Hazardous Substances Data)

Usage

Uses

N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide can be used for preparation of heterocyclyl-substituted piperazines for the prevention or treatment of a disease mediated by the binding of adhesion molecules to GPIIb/IIIa.

Upstream product

• 99-92-3 p-aminobenzophenone 
• 98-59-9 p-toluenesulfonyl chloride 
• 5317-94-2 4-(p-toluenesulfonylamino)acetophenone 

Downstream Products

• 166950-34-1 N-[4-[2-[4-(4-pyridyl)piperazin-1-yl]acetyl]phenyl]-4-methylphenylsulphonamide 
• 871832-28-9 C₁₇H₁₇NO₄S₂ 

Relevant articles and documents

Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators

Pyruvate kinase M2 isoform (PKM2) is a crucial protein responsible for aerobic glycolysis of cancer cells. Activation of PKM2 may alter aberrant metabolism in cancer cells. In this study, we discovered a 4-hydroxy-thiazolidine-2-thione compound 2 as a novel PKM2 activator from a random screening of an in-house compound library. Then a series of novel 4-hydroxy-thiazolidine-2-thione derivatives were designed and synthesized for screening as potent PKM2 activators. Among these, some compounds showed higher PKM2 activation activity than lead compound 2 and also exhibited significant anti-proliferative activities on human cancer cell lines at nanomolar concentration. The compound 5w was identified as the most potent antitumor agent, which showed excellent anti-proliferative effects with IC50 values from 0.46 μM to 0.81 μM against H1299, HCT116, Hela and PC3 cell lines. 5w also showed less cytotoxicity in non-tumor cell line HELF compared with cancer cells. In addition, Preliminary pharmacological studies revealed that 5w arrests the cell cycle at the G2/M phase in HCT116 cell line. The best PKM2 activation by compound 5t was rationalized through docking studies.

Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines.

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