53189-89-2Relevant academic research and scientific papers
Substituted 1 and 2 naphthol mannich bases
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, (2008/06/13)
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.
Subtituted indole mannich bases
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, (2008/06/13)
The invention relates to substituted indole Mannich bases of formula (I), a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments, especially medicaments that are used to treat pain. In formula (I), R1,R2, R4-R7 have the meanings cited in claim 1, R3=formula (a) and R13=(substituted) phenyl.
New Syntheses of Methyleniminium Salts from Carbonyl Compounds and from α-Chloro Ethers; an Access to Vinylogous Viehe Salts
Schroth, Werner,Jahn, Ullrich,Stroehl, Dieter
, p. 2013 - 2022 (2007/10/02)
Two methods for the synthesis of isolable methyleniminium salts and amidinium salts are presented.In the first case carbonyl compounds A are treated with a mixture of (dialkylamino)trimethylsilane (12) and chlorotrimethylsilane (13) or 12 and trimethylsilyl triflate (14) leading to the iminium chlorides F or iminium triflates G, respectively.With 12/13 the preparation of F is limited to non-enolizable aldehydes and dimethylformamide (10), while 12/14 enables the preparation of G, e.g. 23a-25a, 27a, also with ketones and with substituted amides.The second procedure is based on the treatment of α-chloro ethers L with 12.Both methods afford the Mannich reagent 16a in high yields.By reaction of the α-chloro ether 35 with 12 in diethyl ether the vinylogous Viehe salts 36a-c, e become available for the first time.The reaction pathways are discussed. - Key Words: Methyleniminium salts, preparation, mechanisms of formation / (Dialkylamino)trimethylsilanes / Ethers, α-chloro / Viehe salts, vinylogous
