532-05-8

Basic information

• Product Name: 1,3-di-6-quinolylurea
• Synonyms: 1,3-di-6-quinolylurea;1,3-Bis(6-quinolyl)urea;N,N'-Di(6-quinolinyl)urea;1,3-di(quinolin-6-yl)urea
• CAS NO: 532-05-8
• Molecular Formula: C₁₉H₁₄N₄O
• Molecular Weight: 314.34066
• EINECS: 208-525-9
• Mol File: 532-05-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 463.5°Cat760mmHg
• Flash Point: 234.1°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 9.02E-09mmHg at 25°C
• Refractive Index: 1.81
• CAS DataBase Reference: 1,3-di-6-quinolylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-di-6-quinolylurea(532-05-8)
• EPA Substance Registry System: 1,3-di-6-quinolylurea(532-05-8)

Safety Data

• Hazardous Substances Data: 532-05-8(Hazardous Substances Data)

Usage

Chemical compound

1,3-di-6-quinolylurea is a chemical compound consisting of two quinoline rings attached to a urea molecule.

Reagent for zinc detection

It is used as a reagent for the detection and determination of zinc ions in a solution.

Complex formation

1,3-di-6-quinolylurea forms a complex with zinc ions, which results in a color change.

Colorimetric analysis

The color change upon complex formation can be used to measure the concentration of zinc in a solution through colorimetric analysis.

Applications in analytical chemistry

It has potential applications in analytical chemistry, particularly for the detection and measurement of zinc ions.

Environmental monitoring

1,3-di-6-quinolylurea can be used in environmental monitoring to accurately measure the presence of zinc in various samples.

Organic synthesis

1,3-di-6-quinolylurea may have potential uses in organic synthesis, although further research is required to explore its full range of applications.

Medicinal chemistry

It may also have potential applications in medicinal chemistry, but more research is needed to determine its specific uses in this field.

Further research needed

The full range of possible applications for 1,3-di-6-quinolylurea in organic synthesis and medicinal chemistry is not yet fully understood and requires additional research.

InChI:InChI=1/C19H14N4O/c24-19(22-15-5-7-17-13(11-15)3-1-9-20-17)23-16-6-8-18-14(12-16)4-2-10-21-18/h1-12H,(H2,22,23,24)

Upstream product

• 75-44-5 phosgene 
• 580-15-4 6-aminoquinoline 
• 300395-49-7 quinolinyl-6-carbamic acid ethyl ester 
• 57-13-6 urea 
• 5332-25-2 6-bromoquinoline 
• 3582-05-6 trifluoromethyl trifluoromethanesulfonate 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 613-50-3 6-nitroquinoline 

Downstream Products

• 135-14-8 1,1'-dimethyl-6,6'-ureylene-bis-quinolinium; bis-methyl sulfate 

Relevant articles and documents

Concise and Additive-Free Click Reactions between Amines and CF3SO3CF3

Trifluoromethyl trifluoromethanesulfonate has proved to be an excellent reservoir of difluorophosgene and a promising click ligation for amines in the preparation of urea derivatives, heterocycles, and carbamoyl fluorides under metal- and additive-free conditions. The reactions are rapid, efficient, selective, and versatile, and can be performed in benign solvents, giving products in excellent yields with minimal efforts for purification. The characteristics of the reactions meet the requirements of a click reaction. The use of trifluoromethyl trifluoromethanesulfonate as a click reagent is advantageous over other “CO” sources (e.g., TsOCF3, PhCO2CF3, CsOCF3, AgOCF3, and triphosgene) because this reagent is readily accessible; easy to scale up; and highly reactive, even under metal- and additive-free conditions. It is anticipated that CF3SO3CF3 will be increasingly as important as SO2F2 as a click agent in future drug design and development.