53226-55-4

Usage

InChI:InChI=1/C11H13ClO/c1-11(2,3)10(13)8-5-4-6-9(12)7-8/h4-7H,1-3H3

Upstream product

• 2259-30-5 tert-butylmagnesium bromide 
• 587-04-2 m-Chlorobenzaldehyde 
• 3282-30-2 pivaloyl chloride 
• 24344-58-9 tributyl(3-chlorophenyl)stannane 
• 766-84-7 3-chloro-benzonitrile 
• 677-22-5 tert-butylmagnesium chloride 
• 108-37-2 1-bromo-3-chlorobenzene 

Downstream Products

• 1225954-49-3 1-(5-chloro-2-hydroxyphenyl)-2,2-dimethylpropan-1-one 
• 1415419-34-9 1-(3-chloro-2-hydroxyphenyl)-2,2-dimethylpropan-1-one 
• 880473-91-6 1-(5-chloro-2-nitrophenyl)-2,2-dimethylpropan-1-one 
• 120136-22-3 3-Nitro-benzenesulfonic acid 1-(3-chloro-phenyl)-2,2-dimethyl-propyl ester 
• 120136-10-9 1-tert-Butyl-1-(3'-chlorophenyl)methyl tosylate 

Relevant academic research and scientific papers

Catalyst-free alkanoylation of aromatic rings via arylstannanes. Scope and limitations

The reaction of alkanoyl chlorides with arylstannanes in 1,2-dichlorobenzene (180 °C) is a simple and direct route for the catalyst-free and regioselective synthesis of tertiary alkyl aryl ketones in good to excellent isolated yields (55-77%). Nevertheles

Preparation of polyfunctional arylmagnesium, arylzinc, and benzylic zinc reagents by using magnesium in the presence of LiCl

The presence of LiCl considerably facilitates the insertion of magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as -OBoc, -OTs, -Cl, -F, -CF3, -OMe, -NMe2, and -N 2NR2, are well tolerated. The presence of a cyano group leads in some cases to competitive reduction of the organic halide to the corresponding ArH compound. The presence of sensitive groups such as methyl or ethyl ester is tolerated upon in situ trapping of the intermediate magnesium reagent with ZnCl2. This method can also be applied to the preparation of functionalized benzylic zinc reagents from benzylic chlorides. In the case of di- or tribromoaryl derivatives, directing groups such as -OPiv, -OTs, -N2NR2, or -OAc orient the zinc insertion (Zn/LiCl) to the ortho-position, while the reaction with Mg/LiCl or Mg/LiCl/ZnCl 2 leads to regioselective insertion into the para-carbon-bromine bond. Large-scale experiments (20-100 mmol) for all of the metalation procedures are described.

Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives

Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.