3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE

Base Information

• Chemical Name: 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE
• CAS No.: 53226-55-4
• Molecular Formula: C11H13ClO
• Molecular Weight: 196.677
• Hs Code.: 2914700090
• Mol file: 53226-55-4.mol

Synonyms:3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE;1-(3-chlorophenyl)2,2-dimethylpropan-1-one;1-(3-chlorophenyl)-2,2-dimethyl-1-propanone;1-(3-chlorobiphenyl)-2,2-dimethylpropan-1-one;

Chemical Property of 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 0.00582mmHg at 25°C
• Boiling Point: 273.2oC at 760 mmHg
• Flash Point: 150.2oC
• PSA: 17.07000
• Density: 1.077g/cm3
• LogP: 3.56880

Purity/Quality:

95% ^*data from raw suppliers

3'-Chloro-2,2-dimethylpropiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE

There total 4 articles about 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-chloro-benzonitrile (766-84-7) + tert-butylmagnesium chloride (677-22-5) → 1-(3-chlorobiphenyl)-2,2-dimethylpropan-1-one (53226-55-4)

Guidance literature:

3-chloro-benzonitrile; tert-butylmagnesium chloride; copper(l) chloride; In tetrahydrofuran; for 20h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

With water; hydrogenchloride; at 90 ℃; for 1h;

Reference yield: 69.0%

1-bromo-3-chlorobenzene (108-37-2) + pivaloyl chloride (3282-30-2) → 1-(3-chlorobiphenyl)-2,2-dimethylpropan-1-one (53226-55-4)

Guidance literature:

1-bromo-3-chlorobenzene; With magnesium; lithium chloride; In tetrahydrofuran; at 25 ℃; for 0.166667h; Inert atmosphere;

With CCl₂CuN^(2-)*2Li⁽¹⁺⁾; In tetrahydrofuran; at -10 ℃; for 0.25h; Inert atmosphere;

pivaloyl chloride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.200900575

Reference yield: 66.0%

pivaloyl chloride (3282-30-2) + tributyl(3-chlorophenyl)stannane (24344-58-9) → 1-(3-chlorobiphenyl)-2,2-dimethylpropan-1-one (53226-55-4)

Guidance literature:

In 1,2-dichloro-benzene; at 180 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2009.07.019

upstream raw materials:

1-bromo-3-chlorobenzene

pivaloyl chloride

tert-butylmagnesium bromide

m-Chlorobenzaldehyde

Downstream raw materials:

1-(5-chloro-2-hydroxyphenyl)-2,2-dimethylpropan-1-one

1-(3-chloro-2-hydroxyphenyl)-2,2-dimethylpropan-1-one

1-(5-chloro-2-nitrophenyl)-2,2-dimethylpropan-1-one

3-Nitro-benzenesulfonic acid 1-(3-chloro-phenyl)-2,2-dimethyl-propyl ester

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