53234-67-6

Basic information

• Product Name: Morpholine, 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]-
• CAS NO: 53234-67-6
• Molecular Formula: C16H22N2O
• Molecular Weight: 258.363
• Mol File: 53234-67-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]-(53234-67-6)
• EPA Substance Registry System: Morpholine, 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]-(53234-67-6)

Safety Data

• Hazardous Substances Data: 53234-67-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 28637-50-5 morpholine amide of 3-carboxy-2-butanone 
• 110523-75-6 2-benzyl-2,3-dimethyl-5,6,7,8-tetrahydro-6-azachromone 
• 78-93-3 butanone 
• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 132532-20-8 4-(1-benzyl-3-chloro-1,2,3,6-tetrahydro-4-pyridyl)-morpholine 
• 132532-25-3 1α,5α,6β-3-benzyl-6-morpholino-3-azabicyclo<3.1.0>hexane-6-carbonitrile 
• 144774-11-8 6-benzyl-2-ethyl-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridin-4-one 
• 54629-30-0 10H-benzopyrano[3,2-c]pyridin-10-one 
• 110523-74-5 2-benzyl-1,2,3,4,5,6,7,8-octahydro-2-azaxanthone 
• 28637-51-6 morpholine amide of 2-carboxycyclohexanone 
• 110523-76-7 6-benzyl-2-phenyl-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridin-4-one 
• 54568-58-0 1-(morpholin-4-yl)-3-phenylpropane-1,3-dione 
• 98-86-2 acetophenone 
• 104763-55-5 5-benzyl-7a-morpholin-4-yl-1-phenyl-3a,4,5,6,7,7a-hexahydro-1H-[1,2,3]triazolo[4,5-c]pyridine 

Relevant articles and documents

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-selective MTHFD2 inhibitor is highly attractive for potential use in cancer treatment. Herein, we disclose a novel isozyme-selective MTHFD2 inhibitor DS44960156, with a tricyclic coumarin scaffold, which was initially discovered via high-throughput screening (HTS) and improved using structure-based drug design (SBDD). DS44960156 would offer a good starting point for further optimization based on the following features: (1) unprecedented selectivity (>18-fold) for MTHFD2 over MTHFD1, (2) a molecular weight of less than 400, and (3) good ligand efficiency (LE).

Synthesis of 3-azabicyclo[3.3.1]Nonane-6,9-diones

A one pot synthesis of 3-azabicyclo[3.3.1]nonane-6,9-diones is described via the additibn of acryloyl chloride to enamines of N-carboxy-4 piperidones. Yields of bicycle were highest when additions were made to vigorously boiling solutions of morpholine en