53235-97-5Relevant academic research and scientific papers
Copper-mediated 1,4-conjugate addition of boronic acids and indoles to vinylidenebisphosphonate leading to gem-bisphosphonates as potential antiresorption bone drugs
Chiminazzo, Andrea,Sperni, Laura,Damuzzo, Martina,Strukul, Giorgio,Scarso, Alessandro
, p. 2712 - 2718 (2015/03/31)
A wide range of gem-bisphosphonate tetraethyl esters as precursors for bisphosphonic acids, which are potent inhibitors of bone resorption, bearing alkyl, aryl, and indole substituents in the β position were prepared through the CuII-catalyzed 1,4-conjugate addition of boronic acids and indoles to vinylidenebisphosphonate tetraethyl ester.
Water enhanced synthesis of gem-bisphosphonates via Rh(i) mediated 1,4-conjugate addition of aryl boronic acids to vinylidenebisphosphonate esters
Bianchini, Giulio,Scarso, Alessandro,Chiminazzo, Andrea,Sperni, Laura,Strukul, Giorgio
supporting information, p. 656 - 662 (2013/03/29)
A new synthetic method characterized by low environmental impact for the synthesis of a wide range of gem-bisphosphonates bearing aryl substituents in β position as potential anti-resorption species to contrast osteoporosis is reported. The pivotal role p
