5324-15-2Relevant articles and documents
Cascade Functionalization of C(sp3)-Br/C(sp2)-H Bonds: Access to Fused Benzo[ e]isoindole-1,3,5-trione via Visible-Light-Induced Reductive Radical Relay Strategy
Zhu, Jia-Nan,Wang, Wen-Kang,Zhu, Yuan,Hu, Yin-Qiu,Zhao, Sheng-Yin
, p. 6270 - 6274 (2019)
A reductive radical relay strategy for the construction of fused benzo[e]isoindole-1,3,5-trione through a reaction of α-bromo ketones with maleimides in the presence of Ir(ppy)3 under visible-light irradiation is described. The protocol employs very mild reaction conditions and offers satisfactory yields. Moreover, the reaction proceeds through a cascade C(sp3)-Br/C(sp2)-H functionalization, double C-C bond formation, and oxidative aromatization sequence.
Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
Cui, Yi-Man,He, Yan-Ping,Huang, Si-Ming,Li, Sui-Yuan,Li, Xiao-Li,Li, Yi-Ming,Luo, Rong-Hua,Ni, Dong-Xuan,Tang, E.,Xiao, Wei-Lie,Yang, Liu-Meng,Zhang, Hong-Bin,Zhang, Rui-Han,Zhang, Xing-Jie,Zheng, Yong-Tang,Zheng, Yu-Gui
, (2020/07/21)
In order to discover and develop the new HIV-1 NNRTIs, a series of 5-alkyl-6-(benzo[d][1,3]dioxol-5-ylalkyl)-2-mercaptopyrimidin-4(3H)-ones was synthesized and screened for their in vitro cytotoxicity against HIV-1. Most of the compounds we synthetized sh
Stereoselective synthesis of cis-2,6-disubstituted morpholines and 1,4-oxathianes by intramolecular reductive etherification of 1,5-diketones
Gharpure, Santosh J.,Anuradha, Dandela,Prasad, Jonnalagadda V. K.,Rao, Pidugu Srinivasa
, p. 86 - 90 (2015/01/16)
A simple and efficient, Lewis acid catalysed reductive etherification strategy for the stereoselective synthesis of cis-2,6- disubstituted morpholines and 1,4-oxathianes starting from readily available 1,5-diketones has been developed. The strategy is used in the total synthesis of morpholine-based natural products (±)-chelonin A and formal total synthesis of (±)-chelonin C.
USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME
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, (2010/08/18)
The invention provides a reagent for detecting amyloid in a biological tissue which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid and is suppressed in toxicity such as mutagenicity. The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or a nitrogen, and R3 is a group represented by the following formula: wherein R1 is a radioactive halogen substituent; m is an integer of 0 to 4; and n is an integer of 0 or 1, provided that at least one of A1, A3, A3 and A4 represents a carbon, and R5 binds to a carbon represented by A1, A2, A3 or A4.