532421-08-2Relevant academic research and scientific papers
Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers
Wang, Zhao,Shi, Xuan-Hong,Wang, Jia,Zhou, Tian,Xu, You-Zhi,Huang, Ting-Ting,Li, Yan-Fang,Zhao, Ying-Lan,Yang, Li,Yang, Sheng-Yong,Yu, Luo-Ting,Wei, Yu-Quan
, p. 1097 - 1101 (2011/04/16)
A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.
