53244-92-1

Usage

Uses

Used in Molecular Biology and Genetic Research:
(2-oxo-1,2-dihydro-quinolin-3-yl)-acetic acid is used as a reactant in the preparation of peptide nucleic acid (PNA) monomers with non-standard bases. These monomers are essential for the development of triple-helix forming oligomers containing them, which are crucial for nucleic acid hybridization via thymidine targeting. This application is particularly important in the study of genetic mutations, gene regulation, and the development of new therapeutic strategies for various diseases.

Upstream product

• 2721-59-7 3-methylcarbostyril 
• 529-23-7 o-aminobenzaldehyde 
• 872264-80-7 4-((2-formylphenyl)amino)-4-oxobutanoic acid 

Downstream Products

• 80356-63-4 methyl α-(2-quinolon-3-yl)cinnamate 
• 80356-74-7 3-(2'-phenylethyl)-quinolin-2-(1H)-one 
• 80356-55-4 α-(2-quinolon-3-yl)-cinnamic acid 
• 80356-58-7 3-styrylquinolin-2-(1H)-one 
• 61020-60-8 2-chloro-1-(4-methoxy-phenyl)-1H-pyrrolo[2,3-b]quinoline 
• 61020-59-5 2-chloro-1-p-tolyl-1H-pyrrolo[2,3-b]quinoline 
• 115126-08-4 2-Chloro-1-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]quinoline 
• 115126-42-6 1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrolo[2,3-b]quinoline 
• 115126-36-8 1-(4-Methoxy-phenyl)-1H-pyrrolo[2,3-b]quinoline 
• 115126-41-5 1-(p-tolyl)-2,3-dihydro-1H-pyrrolo[2,3-b]quinoline 
• 115126-07-3 2-Chloro-1-phenyl-1H-pyrrolo[2,3-b]quinoline 
• 115126-40-4 1-phenyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinoline 
• 115126-35-7 1-p-Tolyl-1H-pyrrolo[2,3-b]quinoline 
• 115126-34-6 1-phenyl-1H-pyrrolo[2,3-b]quinoline 

Relevant academic research and scientific papers

Electrophilic Substitution in 3- and 4-Methyl-2(1H)quinolinone through Metallated Species

Unprotected 3- (2) and 4-methyl-2(1H)quinolinones (3a) and 4-methyl-5,8-dimethoxy-2(1H)quinolinone (3b) undergo through regioselective lithiation chain enlargement with different electrophiles.