5326-77-2

Basic information

• Product Name: 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• CAS NO: 5326-77-2
• Molecular Formula: C₇H₈ClN₅
• Molecular Weight: 197.6249
• Mol File: 5326-77-2.mol
• Article Data: 1

Chemical Properties

• Density: 1.57g/cm³
• Refractive Index: 1.73
• CAS DataBase Reference: 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine(5326-77-2)
• EPA Substance Registry System: 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine(5326-77-2)

Safety Data

• Hazardous Substances Data: 5326-77-2(Hazardous Substances Data)

Usage

Chemical classification

Pyrazolopyrimidine derivative

Functional groups

Chloro group (-Cl), two methyl groups (-CH3)

Potential applications

Pharmaceutical industry, particularly in drug development

Biological activities

Possible enzyme inhibition, receptor agonism/antagonism, or other pharmacological effects

Research status

Further research and testing required to fully understand properties and potential uses

Upstream product

• 5401-15-0 1-Methyl-1H-pyrazolo<3,4-d>pyrimidine-4,6(5H,7H)-dione 
• 98141-42-5 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 
• 74-89-5 methylamine 

Relevant articles and documents

The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design

We have identified a novel PDE2 inhibitor series using fragment-based screening. Pyrazolopyrimidine fragment 1, while possessing weak potency (Ki = 22.4 μM), exhibited good binding efficiencies (LBE = 0.49, LLE = 4.48) to serve as a start for structure-based drug design. With the assistance of molecular modeling and X-ray crystallography, this fragment was developed into a series of potent PDE2 inhibitors with good physicochemical properties. Compound 16, a PDE2 selective inhibitor, was identified that exhibited favorable rat pharmacokinetic properties.