53295-33-3

Upstream product

• 15206-97-0 Ethyl α-acetyl-β-anilino-β-phenylpropionate 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 141-97-9 ethyl acetoacetate 
• 538-51-2 benzylidene phenylamine 

Relevant academic research and scientific papers

Efficient synthesis of piperidine derivatives using dendrimer based catalytical pockets

The synthesis of highly functionalized piperidine derivatives using amine functionalized maltitol-cored dendritic polymer (MAL-G0) in acetonitrile as the reaction medium is reported. A variety of piperidine derivatives were synthesized and the reaction ga

Highly effective synthesis of 1-thioamidoalkyl-2-naphthols and tetrahy-dropyridines using a nanostructured silica-based catalyst under mild conditions

Aim and Objective: Nano-2-[N',N'-dimethyl-N'-(silica-n-propyl)ethanaminium chlo-ride]-N,N-dimethylaminium bisulfate (nano-[DSPECDA][HSO4 ]) was used as a highly effective and heterogeneous silica-based nanostructured catalyst for the synthesis of 1-thioamidoalkyl-2--naphthols and substituted tetrahydropyridines. Material and Methods: The expected products were prepared in mild conditions. In this work, three novel 1-thioamidoalkyl-2-naphthols and two new tetrahydropyridine derivatives were synthe-sized and characterized by IR,1H and13C NMR and Mass spectroscopy. Results: One-pot multi-component condensation of 2-naphthol with arylaldehydes and thioace-tamide catalyzed by nano-[DSPECDA][HSO4 ] under green, mild and solvent-free conditions led to 1-thioamidoalkyl-2-naphthols in high yields. The nanocatalyst was also used for the preparation of functionalized tetrahydropyridines by the one-pot multi-component reaction of anilines, arylaldehy-des and ethylacetoacetate under solvent-free and mild conditions. Conclusion: The reaction results were found to be better compared to the literature in terms of one or more of these factors: yield, time, and the reaction media. All the products were purified by re-crystallization from EtOH, and without column chromatography, being in good agreement with the green chemistry protocols.

Bis(1,3-dimethylimidazolidinone) hydrotribromide (DITB) promoted multicomponent reaction for the synthesis of highly functionalized piperidines

A convenient and efficient method has been developed for the synthesis of highly functionalized piperidines via three-component, one-pot domino reaction of β-ketoesters, aromatic aldehydes, and anilines in the presence of catalytic amount of bis(1,3-dimethylimidazolidinone) hydrotribromide (DITB) in ethanol at room temperature.

Aluminized polyborate: a novel catalyst for the multicomponent solvent-free synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates

Abstract: An efficient and simple method for the one-pot three-component synthesis of alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxylates was developed using aromatic aldehyde, amine and β-ketoesters catalyzed by aluminized polyborate, an efficient reusable catalyst under solvent-free condition. Aluminized polyborate has advantageous of cost, ecologically benefits, accessible preparation and recyclability up to five cycles along with high product yield and simplicity. Graphical Abstract: [Figure not available: see fulltext.].

Diastereoselective synthesis of symmetrical and unsymmetrical tetrahydropyridines catalyzed by Bi(III) Immobilized on triazine dendrimer stabilized magnetic nanoparticles

Unsymmetrical 1,2,5,6-tetrahydropyridine-3-carboxylates were obtained for the first time from a five-component Fe3O4@TDSN-Bi(III)-catalyzed reaction of aryl aldehydes, aryl amines, and ethyl acetoacetate. This magnetically separable

MgFe2O4/cellulose/SO3H nanocomposite: a new biopolymer-based nanocatalyst for one-pot multicomponent syntheses of polysubstituted tetrahydropyridines and dihydropyrimidinones

A new biopolymer cellulose-based magnetic heterogeneous catalyst, MgFe2O4/cellulose/SO3H nanocomposite, was prepared. Fourier-transform infrared spectra, X-ray diffraction, energy-dispersive X-ray, field-emission scanning electron microscopy, thermal analysis (TG, DTG and DSC), dynamic light scattering and vibrating sample magnetometer measurements have been used to characterize the catalyst. Then, it was applied efficiently as an inexpensive and green catalyst in two multicomponent syntheses of polysubstituted tetrahydropyridines and dihydropyrimidinones under solvent-free conditions. The nanocatalyst can be recovered and reused several times without significant loss of catalytic activity.

NO2-Fe(III)PcCl@C -catalyzed one-pot synthesis of tetrahydropyridine derivatives

A highly efficient, one-pot synthesis of functionalized tetrahydropyridines by multicomponent condensation of ethyl acetoacetate, two equivalents of aromatic aldehyde, and aromatic amine in the presence of a catalytic amount of NO2-Fe(III)PcCl@

A method for utilizing acidic ionic liquid catalytic preparation of tetrahydro pyridine derivatives

The invention discloses a method for catalized preparation of a tetrahydropyridine derivative through acidic ionic liquid, and belongs to the technical field of the organic chemical industry. In the preparation reaction, the molar ratio of aromatic amine

Alum as an efficient catalyst for the multicomponent synthesis of functionalized piperidines

An effective approach to the synthesis of functionalized piperidines via a one-pot multicomponent reaction of aniline, β-ketoester and aldehyde in the presence of alum as an efficient catalyst has been reported. The present procedure offers advantages such as simple workup, short reaction time and offers rapid access to a variety of functionalized piperidines.