5331-42-0

Basic information

• Product Name: 2-CYANO-3-PHENYLPROPIONIC ACID
• Synonyms: 2-CYANO-3-PHENYLPROPIONIC ACID
• CAS NO: 5331-42-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 5331-42-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 169.9°C
• Appearance: /
• Vapor Pressure: 9.97E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CYANO-3-PHENYLPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-3-PHENYLPROPIONIC ACID(5331-42-0)
• EPA Substance Registry System: 2-CYANO-3-PHENYLPROPIONIC ACID(5331-42-0)

Safety Data

• Hazardous Substances Data: 5331-42-0(Hazardous Substances Data)

Usage

General Description

2-Cyano-3-Phenylpropionic Acid, also known as 2-CCPA, is a chemical compound used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a white crystalline powder with a molecular formula of C10H9NO2 and a molecular weight of 175.18 g/mol. 2-CYANO-3-PHENYLPROPIONIC ACID is a derivative of phenylpropionic acid, which possesses analgesic and anti-inflammatory properties. It is commonly utilized as a starting material for the production of non-steroidal anti-inflammatory drugs (NSAIDs) and other pharmaceuticals. Additionally, 2-CCPA is used as a building block for the synthesis of biologically active compounds, making it an important chemical in the pharmaceutical industry.

InChI:InChI=1/C10H9NO2/c11-7-9(10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6H2,(H,12,13)/p-1/t9-/m1/s1

Upstream product

• 6731-58-4 ethyl 2-cyano-3-phenylpropanoate 
• 1011-92-3 2-cyano-3-phenylacrylic acid 
• 7732-18-5 water 
• 124-38-9 carbon dioxide 
• 645-59-0 dihydrocinnamonitrile 
• 1885-38-7 cinnamic nitrile 
• 100-44-7 benzyl chloride 

Downstream Products

• 92554-56-8 3-phenyl-2-phenylhydrazono-propionitrile 
• 62039-31-0 3-phenyl-2-p-tolylhydrazono-propionitrile 
• 138763-53-8 2-cyano-3-phenyl-propionyl chloride 
• 645-59-0 dihydrocinnamonitrile 
• 148549-97-7 N-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]phenyl]-α-cyano-benzenepropanamide 
• 62448-27-5 2-bromo-3-phenylpropanenitrile 
• 4443-06-5 α-(aminocarbonyl)benzenepropanoic acid 
• 124-38-9 carbon dioxide 
• 57519-78-5 methyl 2-cyano-4-phenylpropanoate 
• 10603-56-2 3-benzyl-1-methylpyrrolidine-3-carbonitrile 
• 1448002-13-8 methyl 1-[3-oxopropyl-1-phenyl-2-cyano-3-(cyclohexylamino)]cyclohexylcarboxylate 
• 102-93-2 3-phenylpropionamide 
• 36963-38-9 3-phenyl-2-phenylhydrazono-propionic acid 
• 88518-48-3 2-Acetimino-1,3-dibenzyl-5-ethoxycarbonyl-6-methyl-1,2-dihydropyridin 

Relevant articles and documents

Double decarboxylative route to 3-substituted pyrrolidines: Reaction of monoalkyl malonates and related carboxylic acids with sarcosine and formaldehyde

Three-component reactions of monoalkyl malonates, cyanoacetic acids or 2-ketocarboxylic acids, N-methylglycine, and formaldehyde were developed to rapidly access 3-substituted pyrrolidines in 17–97% yield. These reactions represent a double decarboxylative domino-sequence promoted by pyrrolidine and involve N-methylazomethine ylide as the reactive intermediate.

Cobalt-catalyzed reductive carboxylation on α,β-unsaturated nitriles with carbon dioxide

The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II)

Electrochemical reduction of cinnamonitrile in the presence of carbon dioxide: Synthesis of cyano- and phenyl-substituted propionic acids

Cyano- and phenyl-substituted propionic acids were synthesized simply and efficiently by electrocarboxylation of cinnamonitrile in undivided cells using the non-noble metal nickel as cathode and magnesium as the anode. The radical anion generated by the e