5331-62-4

Usage

Uses

Used in Organic Synthesis:
2-(Thiophen-2-yl)propan-2-ol is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its unique structure, which includes a thiophene ring, allows for the development of a wide range of chemical compounds with diverse applications.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
In the pharmaceutical industry, 2-(Thiophen-2-yl)propan-2-ol is employed as a chiral auxiliary in asymmetric synthesis. This application is crucial for the production of enantiomerically pure compounds, which are essential in drug development to ensure the desired therapeutic effects and minimize potential side effects.
Used in Pharmaceutical Industry:
2-(Thiophen-2-yl)propan-2-ol has potential applications in the pharmaceutical industry, where its unique structural features and solubility properties make it a valuable component in the development of new drugs and therapeutic agents. Its role as a building block and chiral auxiliary contributes to the advancement of pharmaceutical research and innovation.

InChI:InChI=1/C7H10OS/c1-7(2,8)6-4-3-5-9-6/h3-5,8H,1-2H3

Upstream product

• 89180-57-4 2-thienylmagnesium iodide 
• 67-64-1 acetone 
• 188290-36-0 thiophene 
• 88-15-3 2-Acetylthiophene 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 

Downstream Products

• 30616-73-0 2-isopropenylthiophene 
• 913254-84-9 2-{(α,α'-dimethyl)hydroxymethyl}-5-{p-tolylhydroxymethyl}thiophene 
• 913254-88-3 2-{5-[hydroxy-(3-nitro-phenyl)-methyl]-thiophen-2-yl}-propan-2-ol 
• 913254-86-1 2-{5-[(4-bromo-phenyl)-hydroxy-methyl]-thiophen-2-yl}-propan-2-ol 
• 913254-87-2 4-{hydroxy-[5-(1-hydroxy-1-methyl-ethyl)-thiophen-2-yl]-methyl}-benzonitrile 
• 913254-85-0 2-{5-[hydroxy-(4-iodo-phenyl)-methyl]-thiophen-2-yl}-propan-2-ol 
• 99605-71-7 2-(2-thienyl)allylamine 
• 88-15-3 2-Acetylthiophene 

Relevant academic research and scientific papers

Hetero-calix[4]pyrroles: Incorporation of furans, thiophenes, thiazoles or fluorenes as a part of the macrocycle

Furans, thiazoles, fluorene or thiophene incorporated calix[4]pyrrole analogues were synthesized and characterized. The synthesis was achieved by utilization of various building blocks such as 7, 13, 14, 18 and 21. Acid catalyzed condensation of those building blocks with acetone or meso-disubstituted dipyrromethanes afforded desired macrocycles.

Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can enha

Synthesis and anion-binding studies of thiaphlorins and covalently linked thiaphlorin-porphyrin dyads

A series of thiaphlorins with N2S2 and N3S cores have been prepared in decent yields from readily available precursors. The thiaphlorins were characterized by all spectroscopic techniques and the structures of two thiaphlo

Synthesis of functionalized thia analogues of phlorins and covalently linked phlorin-porphyrin dyads

The 21,23-dithia and 21-thia analogues of phlorins and mono-functionalized thiaphlorins were synthesized using easily available precursors and the mono-functionalized thiaphlorins were used further to synthesize the first examples of three covalently link

STUDIES TOWARD ALKYLTHIOPHENE-2-CARBOXALDEHYDES. REDUCTION OF 3-ALKENYLTHIOPHENES WITH TRIETHYLSILANE/TRIFLUOROACETIC ACID. REGIOSELECTIVTY IN FORMYLATION REACTIONS OF ALKYLTHIOPHENES

Reduction of 2- or 3-alkenylthiophenes with Et3SiH/CF3CO2H in CH2Cl2 gives the corresponding 2- or 3-alkylthiophene in >90percent isolated yield.The regioselectivity of various Vilsmeier formylations of 3-alkylthiophenes was found to be a function of increasing steric bulk in the 3-alkyl substituent and in the Vilsmeier reagent.The regioselectivty of formylations of 3-alkylthiophenes by initial lithiation with butyllithium in ether followed quenching with DMF is independent of the presence or absence of TMEDA.

Use of 2-Thienyl, 2-Furyl, 5-Ethyl-2-furyl, and Protonated 4-Acetylphenyl Substituents in Carbon-14 Nuclear Magnetic Resonance Chemical Shift Correlations

The application of the tool of increasing electron demand has been extended by employing increased electron-withdrawing as well as electron-donating substituents.In combination with the electron-withdrawing 4-protonated acetylphenyl substituent and the el