5333-03-9

Basic information

• Product Name: 2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione
• Synonyms: 2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione
• CAS NO: 5333-03-9
• Molecular Formula: C₂₀H₁₆O₄
• Molecular Weight: 320.3386
• Mol File: 5333-03-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 516.9°Cat760mmHg
• Flash Point: 229°C
• Appearance: /
• Density: 1.239g/cm³
• Vapor Pressure: 8.6E-11mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione(5333-03-9)
• EPA Substance Registry System: 2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione(5333-03-9)

Safety Data

• Hazardous Substances Data: 5333-03-9(Hazardous Substances Data)

Usage

General Description

2,5-Bis(4-methoxyphenyl)-2,5-cyclohexadiene-1,4-dione, also known as p-Benzoquinone, is a chemical compound that belongs to the class of benzoquinones. It is a yellow crystalline solid that is widely used in organic synthesis and as a precursor for the production of dyes, pharmaceuticals, and other organic compounds. It is also known for its use in the production of photographic developers and as a reagent in chemical analysis. p-Benzoquinone is a powerful oxidizing agent and is commonly used in organic reactions as a mild oxidizing agent. It is also known to possess antifungal and antibacterial properties, making it useful in the preservation of food and other organic materials.

InChI:InChI=1/C20H16O4/c1-23-15-7-3-13(4-8-15)17-11-20(22)18(12-19(17)21)14-5-9-16(24-2)10-6-14/h3-12H,1-2H3

Upstream product

• 100-66-3 methoxybenzene 
• 106-51-4 p-benzoquinone 
• 30100-35-7 p-anisyl-p-benzoquinone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2674-34-2 1,4-dibromo-2,5-dimethoxybenzene 
• 206867-53-0 4,2',5',4''-Tetramethoxy-[1,1';4',1'']terphenyl 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 14839-81-7 4-methoxy-N-nitrosoacetanilide 
• 51-66-1 4-methoxyacetanilide 
• 150-78-7 1,4-dimethoxybezene 

Relevant articles and documents

Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils

BACE1 activity, inhibition of Aβ aggregation, and disaggregation of preformed Aβ fibrils constitute the three major targets in the development of small-molecule lipophilic new drugs for the treatment of Alzheimer's disease (AD). Quinones are widely distributed among natural products and possess relevant and varied biological activities including antitumor and antibiotic, inhibition of HIV-1 reverse transcriptase, antidiabetic, or COX-inhibition, among others. We report herein the interaction of several arylquinones and their derivatives with the amyloidogenic pathway of the amyloid precursor protein processing. Our studies put forward that these compounds are promising candidates in the development of new drugs which are effective simultaneously towards the three major targets of AD.

Studies on the Meerwein Arylation-Based Preparation of 2,3-Diarylbenzene-1,4-diones and Its Theoretical Interpretation

Title compounds possessing a variety of substituents are systematically prepared by means of Meerwein arylation of benzene-1,4-dione. Synthetic aspects and their MNDO calculation-based interpretation are described.