5333-05-1

Usage

Chemical Properties

WHITE TO SLIGHTLY GREEN CRYSTALLINE POWDER

InChI:InChI=1/C8H6ClNOS/c9-5-1-2-6-7(3-5)12-4-8(11)10-6/h1-3H,4H2,(H,10,11)

Upstream product

• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 96-32-2 bromoacetic acid methyl ester 
• 105-36-2 ethyl bromoacetate 
• 81214-90-6 (2-Hydroxyamino-phenylsulfanyl)-acetic acid 

Downstream Products

• 1208006-14-7 7-chloro-4-[2-(4-fluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-4H-benzo[1,4]thiazin-3-one 
• 1208006-10-3 7-chloro-4-[2-(2,4-difluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propyl]-4H-benzo[1,4]thiazin-3-one 
• 78959-21-4 2,4-dichlorobenzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 
• 78959-22-5 p-nitrobenzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 
• 78959-18-9 o-hydroxybenzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 
• 78959-19-0 p-hydroxybenzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 
• 78959-20-3 p-chlorobenzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 
• 78959-17-8 benzoic acid 2-(7-chloro-2H-1,4-benzothiazin-3-yl)-hydrazide 

Relevant academic research and scientific papers

Synergistic promoting effect of ball milling and KF-alumina support for the green synthesis of benzothiazinones

A solvent-free procedure was developed for the reaction of 2-aminothiophenols with 2-bromoalkanoates, where KF-Al2O3 support and ball milling cooperatively lead to a green and efficient synthesis of several benzothiazinone derivatives in good to excellent yields. The catalyst could be recycled in further reactions while maintaining its activity.

[NO3], a green and base-free medium for one-pot synthesis of benzothiazinones at room temperature

A general and efficient room-temperature procedure is developed for high-yield synthesis of 2H-benzo[b][1,4]thiazin-3(4H)-one derivatives in one pot from the reaction of 2-aminothiophenols with 2-bromoalkanoates in ionic liquid [bmim]NO3 without the use of any catalyst, base, or additive. Products were obtained in good yields by simple extraction with Et2O followed by evaporation of the volatile contents and recrystallization from Et2O. The ionic liquid was recycled and reused in the next reaction without the loss of its activity.

NOVEL COMPOUNDS

The invention relates to tricyclic derivatives, and their use in treating diseases and conditions mediated by antagonism of the mGluR5 receptor, in particular substance related disorders. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.

The Electrochemical Synthesis of Cyclic Hydroxamic Acids Followed by Bamberger Rearrangement

The electrochemical reduction of 2-(o-nitro-phenylthio)acetic acid 1a results in the expected cyclic hydroxamic acid 3a and a rearranged product 4a by consuming 4 electrons.The analogous reduction of 2-(o-nitro-phenoxy)acetic acid 1b leads only to a rearr