5333-13-1

Usage

Uses

Used in Organic Synthesis:
3-bromo-2,4,6-trimethylbenzoic acid is utilized as a key intermediate in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the creation of diverse organic compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-bromo-2,4,6-trimethylbenzoic acid is employed as a starting material or a building block for the development of new drugs, leveraging its unique structure to explore novel therapeutic agents.
Used in Agrochemical Development:
3-bromo-2,4,6-trimethylbenzoic acid is used as a chemical precursor in the design and synthesis of new agrochemicals, potentially leading to the discovery of more effective and environmentally friendly pesticides or herbicides.
Used in Materials Science:
In the field of materials science, 3-bromo-2,4,6-trimethylbenzoic acid is used as a precursor for the synthesis of advanced materials, contributing to the development of new materials with improved properties for various applications.

Upstream product

• 480-63-7 mesitylenecarboxylic acid 
• 56-23-5 tetrachloromethane 
• 7726-95-6 bromine 
• 854652-04-3 1-phenyl-3-(3-bromo-2.4.6-trimethyl-phenyl)-propanedione-(1.2) 
• 7722-84-1 dihydrogen peroxide 
• 855174-40-2 2-hydroxy-1-phenyl-3-(3-bromo-2.4.6-trimethyl-phenyl)-propen-⁽²⁾-one-⁽¹⁾ 

Downstream Products

• 26584-20-3 methyl 3-bromo-2,4,6-trimethyl-benzoate 
• 1597532-47-2 C₂₈H₃₀O₄ 
• 857610-63-0 1-(3-bromo-2,4,6-trimethyl-phenyl)-2-mesityl-propenone 
• 860537-72-0 3-bromo-2,4,6,2',4',6'-hexamethyl-deoxybenzoin 
• 106567-24-2 3-Bromo-2,4,6,N,N-pentamethyl-benzamide 
• 106567-42-4 3-Bromo-2,4,6,N,N-pentamethyl-benzamide 
• 106567-13-9 3-Bromo-2,4,6,N,N-pentamethyl-benzamide 
• 99058-07-8 dibromomesitoic acid 

Relevant academic research and scientific papers

Method for synthesizing hexamethyl terphenyl dimethyl ester

The invention relates to a method for synthesizing hexamethyl terphenyl dimethyl ester. The method comprises the following steps: S1: in an inert atmosphere, at a temperature of -40 DEG C to -50 DEG Cand in the existence of a nucleophilic reagent, the 2,4,6-trimethylbenzoate with meta-position substituted by monohalogen is reacted with trialkyl borate in a first organic solvent or 3 to 5 hours toobtain 3-boric acid-2, 4, 6-methyl trimethyl benzoate; and S2: in an inert atmosphere and under reflux conditions, 3-boric acid-2,4,6-trimethylbenzoic acid methyl ester is reacted with benzene with para-position substituted by subhalogen, inorganic base and a catalyst in a second organic solvent for 16 to 19 hours, and hexamethyl terphenyl dimethyl ester can be obtained. The synthetic method hasthe beneficial effects that the p-dibromobenzene which is inexpensive and readily available is used as a raw material to synthesize hexamethyl terphenyl dimethyl ester, so that the cost is significantly reduced.

Bromination of arenes using I2O5-KBr in water

An efficient and environmentally benign bromination of various aromatic compounds using aN aqueous I2O5-KBr system at room temperature has been developed in this work. A series of aromatic compounds such as acetophenones, benzaldehydes, benzoic acids, anilines, amides, and aminopyridine have been successfully brominated in excellent regioselectivities and good yields under the typical reaction conditions. The features of KBr as brominating reagent, water as solvent, and mild conditions make this system an attractive synthetic procedure. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Chromatographic Separation of Enantiomers and Barriers to Enantiomerization of Axially Chiral Aromatic Carboxamides

The enantiomers (M) and (P) of a series of similar aromatic carboxamides have been, for the first time, investigated analytically and enriched preparatively by liquid chromatography on triacetylcellulose.Enantiomeric purities (7-99percent), specific rotations, and barriers to rotation about the C(sp2)-C(sp2) bond (87 - 120 kJ/mol, Table 5) were determined.These energies are discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.