53338-49-1Relevant academic research and scientific papers
Ring-contraction of hantzsch esters and their derivatives to pyrrolesviaelectrochemical extrusion of ethyl acetate out of aromatic rings
Liu, Xu,Liu, Chang,Cheng, Xu
supporting information, p. 3468 - 3473 (2021/05/21)
Electrochemical ring-contraction of HEs and theirs pyridine derivatives is developed to obtain polysubstituted pyrroles. This process provides an orthogonal utilization of Hantzsch esters for the well-documented application as side chain or hydrogen donors. The formal transformation shows an extrusion of ethyl acetate out of the pyridine ring in a single step. In addition to the novel transformation, we also discovered the Lewis acid's intermolecular control of regioselectivity during an intramolecular electrochemical process. The reaction provides a number of polysubstituted pyrroles that have never been accessed, including pharmaceutical intermediates and photoswitches. An unusual 4-electron continuous reduction drives the unprecedented anionic dearomatization/ring-contraction/rearomatization pathway.
Oxidative-aromatization of hantzsch ester 1,4-dihydropyridines by KBrO 3/Cocl2.6H2O under mild condition
Dilmaghani, Karim Akbari,Zeynizadeh, Behzad,Mirzaei, Mansoor
, p. 139 - 142 (2008/02/12)
KBrO3/CoCl2.6H2O system was used as an effective oxidizing agent for the oxidation of 1,4-dihydropyridines to the corresponding pyridine derivatives in refluxing CH3CN. The products were obtained in high to exce
Solid state photochemistry of 1,4-dihydropyridines
Memarian, Hamid R.,Mirjafari, Arsalan
, p. 3423 - 3425 (2007/10/03)
Photochemical behavior of some 1,4-dihydropyridines has been investigated in the solid state. Whereas upon irradiation of 1,4-dihydropyridines in solution phase, their photo-oxidation and formation of pyridine derivatives have been observed, irradiation o
