21835-71-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 626-34-6 ethyl aminocrotonate 
• 57-13-6 urea 
• 35388-37-5 1-(4-dimethylaminophenyl)-2-ethoxycarbonylbut-1-en-2-one 

Downstream Products

• 101203-29-6 4-(3,5-bis-ethoxycarbonyl-2,6-dimethyl-1,4-dihydro-[4]pyridyl)-N,N-dimethyl-N-propyl-anilinium; iodide 
• 66941-29-5 4-(3,5-bis-ethoxycarbonyl-2,6-dimethyl-1,4-dihydro-[4]pyridyl)-tri-N-methyl-anilinium; iodide 
• 53338-49-1 4-(4-dimethylamino-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and application of chitosan supported vanadium oxo in the synthesis of 1,4-dihydropyridines and 2,4,6-triarylpyridines: Via anomeric based oxidation

Chitosan, as a biopolymer, exhibits a strong affinity for complexation with suitable metal ions. Thus, it has received increased attention for the preparation of stable bioorganic-inorganic hybrid heterogeneous catalysts. Herein, a novel chitosan based vanadium oxo (ChVO) catalyst was prepared and fully characterized by several techniques such as Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), derivative thermal gravimetric (DTG), differential thermal analysis (DTA), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED), X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma mass spectrometry (ICP-MS). The synthesized catalyst has been successfully used as a reusable catalyst in the synthesis of dihydropyridines and triarylpyridines.

Benzyltrimethylammoniumfluoride Hydrate: An Efficient Catalyst for One-Pot Synthesis of Hantzsch 1,4-Dihydropyridines and Their Aromatization

An efficient, cost-effective and simple protocol has been developed for the synthesis of Hantzsch 1,4-dihydropyridines and their oxidation into pyridines using benzyltrimethylammonium fluoride hydrate as an excellent catalyst under solvent-free condition. All of the products synthesized by this method are characterized by various spectroscopic methods (IR, 1H NMR, 13C NMR, and DEPT).

RETRACTED ARTICLE: One-pot synthesis of Hantzsch dihydropyridines using a highly efficient and stable PdRuNi@GO catalyst

Addressed herein, highly monodispersed PdRuNi nanoparticles furnished with graphene oxide (PdRuNi@GO NPs) were prepared as novel, stable, efficient and exceptionally reusable heterogeneous catalysts for 1,4-dihydropyridine synthesis via multicomponent con

Cu-doped ZnO nanocrystalline powder as a catalyst for green and convenient multi-component synthesis of 1,4-dihydropyridine

Abstract A simple, efficient, and convenient one-step method for synthesis of Hantzsch 1,4-dihydropyridine, using Cu-doped ZnO nanocrystalline powder as a catalyst is reported. The method offers several advantages including excellent yields, green solvent, easy work-up, simplicity in operation and catalyst reusability.

Melamine supported on hydroxyapatite-encapsulated-γ-Fe2O3: A novel superparamagnetic recyclable basic nanocatalyst for the synthesis of 1,4-dihydropyridines and polyhydroquinolines

In this paper, the preparation and characterization of hydroxyapatite-encapsulated γ-Fe2O3 nanoparticles functionalized with Melamine nanocomposite (γ-Fe2O3@HAp@Melamine) are presented. The resulting nanocomposite was characterized by infrared spectroscopy, scanning electron microscope, thermal gravimetric analysis, X-ray diffraction, vibrating sample magnetometer and elemental analysis. The catalytic activity of γ-Fe2O3@ HAp@Melamine as a magnetic powerful basic nanocatalyst was probed through one-pot synthesis of 1, 4-dihydropyridine and polyhydroquinoline derivatives through Hantzsch condensation reaction under solvent-free thermal conditions. The heterogeneous catalyst could be recovered easily by simple magnetic decantation and reused many times without significant loss of its catalytic activity.

Recyclable Bi2WO6-nanoparticle mediated one-pot multicomponent reactions in aqueous medium at room temperature

Different types of multicomponent reactions (MCRs) are reported using Bi2O3, BiVO4, and Bi2WO6 (nanoparticle) as heterogeneous catalysts. Among these, Bi2WO6 nanoparticles showed excellent reactivity for the synthesis of functionalized dihydropyridine, polyhydroquinoline, 4H-chromene and 2-amino-4H-benzo[b]pyran derivatives at ambient temperature in aqueous medium. All the reactions gave good to excellent yields in 10-45 minutes in the presence of 5 mol% (optimized) of the catalyst. The catalyst was regenerated and reused up to 5 times without losing catalytic activity. The gram scale synthesis of dihydropyridine gave the desired product in 82% yield in 2 h. This journal is

Comparative study of catalytic potential of TBAB, BTEAC, and CTAB in one-pot synthesis of 1,4-dihydropyridines under aqueous medium

Convenient and straightforward tetrabutylammonium bromide (TBAB), benzyltrienthylammonium chloride (BTEAC), and cetyltrimethylammonium bromide (CTAB) catalyzed synthesis of 1,4-dihydropyridines (1,4-DHPs) in water was established for the first time. The catalytic potential of phase-transfer catalysts (PTCs) in three different concentrations was envisioned. Aryl aldehydes and hetero aryl aldehydes afforded good yields of 1,4-DHPs in TBAB and BTEAC reactions. In particular, furfuraldehyde and thienyl-2-carbaldehyde produced excellent yields. Isolation of the products through nonchromatographic methods, good to excellent yields, and benign reaction conditions are the major advantages of this protocol.

β-Cyclodextrin-polyurethane polymer: A neutral and eco-friendly heterogeneous catalyst for the one-pot synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives via the Hantzsch reaction under solvent-free conditions

An efficient synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives using a β-cyclodextrin-polyurethane polymer (β-CDPU) as a stationary micro-vessel and neutral heterogeneous catalyst via a four component coupling of aldehydes, β-ketoester (2 mol) and ammonium acetate under solvent-free conditions is described. Compared with the classical Hantzsch reaction, this new method has the advantages of good yield, short reaction time and methodological simplicity. β-CDPU was proved to be an efficient heterogeneous catalyst that could be easily handled and removed from the reaction mixture by simple filtration, and also recovered and reused without loss of reactivity.

A magnetic nanoparticle supported Ni2+-containing ionic liquid as an efficient nanocatalyst for the synthesis of Hantzsch 1,4-dihydropyridines in a solvent-free dry-system

The highly efficient synthesis of 1,4-dihydropyridines (1,4-DHPs) is reported via the condensation reaction of aldehydes, ethyl acetoacetate and ammonium acetate, using an environmentally benign Ni2+-containing 1-methyl-3-(3-trimethoxysilylprop

Synthesis of 1, 4-dihydropyridine derivatives using FeCl3 as catalyst under solvent-free condition

A mixture of ethyl acetoacetate, benzaldehyde and ammonium acetate and in the presence of FeCl3 under solvent-free condition were converted to 1, 4-dihydropyridines with good yields.