53361-40-3

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl 2-(4-(benzyloxy)benzylidene)malonate is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of complex molecules with potential therapeutic properties, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, Diethyl 2-(4-(benzyloxy)benzylidene)malonate serves as a precursor in the production of certain agrochemicals. Its reactivity and structural features enable the synthesis of compounds that can be used in pest control and crop protection.
Used in Materials Science:
Diethyl 2-(4-(benzyloxy)benzylidene)malonate may also find applications in materials science due to its potential to form novel materials with unique properties. Its aromatic and ether-like characteristics could be leveraged to develop new polymers, coatings, or other advanced materials with specific applications.
Used in Organic Synthesis:
As a building block in organic synthesis, Diethyl 2-(4-(benzyloxy)benzylidene)malonate is used for the preparation of a wide range of organic compounds. Its versatility in forming different chemical bonds and its compatibility with various reaction conditions make it a valuable component in the synthesis of complex organic molecules for research and industrial purposes.

InChI:InChI=1/C21H22O5/c1-3-24-20(22)19(21(23)25-4-2)14-16-10-12-18(13-11-16)26-15-17-8-6-5-7-9-17/h5-14H,3-4,15H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 105-53-3 diethyl malonate 
• 17315-86-5 2-(4-hydroxybenzylidene)malonic acid diethyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 1427010-07-8 C₂₃H₁₈N₂O₃ 
• 1092074-21-9 C₂₉H₂₂N₂O₃ 

Relevant academic research and scientific papers

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

We have explored here the scope of the age-old diethyl malonate-based accesses to α-amino esters involving Knoevenagel condensations of diethyl malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding α-hydroxyimino esters and their final reduction. This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates - using Suzuki-Miyaura coupling or cycloadditions - before undertaking the oximation step - provided accesses to further α-amino esters. Moreover, other pathways to α-hydroxyimino esters were explored including an attempt to improve the cycloadditions between ethyl β-bromo-α-hydroxyiminocarboxylate and various alkylfuranes.

Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation

The identification of a novel pyrazolidine-3,5-dione based scaffold hit compound as Farnesoid X receptor (FXR) partial or full agonist has been accomplished by means of virtual screening techniques. A series of pyrazolidine-3,5-dione derivatives (1a-u and

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.