Journal of the Chemical Society. Perkin transactions I p. 2079 - 2090 (1996)
Update date:2022-08-04
Topics:
Cassidy, Mark A.
Crockett, Nigel
Leeper, Finian J.
Battersby, Alan R.
A route is devised for synthesis of both enantiomers of the spiro lactam 4. The enzyme uroporphyrinogen III synthase (cosynthetase), which converts hydroxymethylbilane 1 into uroporphyrinogen III 3, is competitively inhibited more than twenty times more s
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