53366-80-6

Upstream product

• 10160-87-9 Propiolaldehyde diethyl acetal 
• 100-52-7 benzaldehyde 
• 81535-78-6 3,3-diethoxy-1-(tributylstannyl)prop-1-yne 
• 98-88-4 benzoyl chloride 
• 53366-79-3 (+/-)-4-hydroxy-4-phenylbut-2-ynal diethyl acetal 

Downstream Products

• 17812-07-6 Benzoylacrylic acid 
• 1148158-67-1 5-(methoxycarbonyl)-4-phenylthiophene-2-carboxylic acid 
• 1400660-91-4 (S)-2-{[5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid 
• 1400661-94-0 5-[3-(tert-Butyl-dimethyl-silanyloxy)-benzylcarbamoyl]-3-phenyl-thiophene-2-carboxylic acid methyl ester 
• 1400661-95-1 5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carboxylic acid 
• 1400661-96-2 (S)-3-tert-Butoxycarbonylamino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester 
• 1400661-98-4 (S)-3-Amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt 
• 1400662-00-1 (S)-2-{[5-(3-Hydroxy-benzylcarbamoyl)-3-phenyl-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid methyl ester 

Relevant academic research and scientific papers

THIAZOLE AND THIOPHENE COMPOUNDS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD

A New Method for the Preparation of (E)-3-Acylprop-2-enoic Acids

A new method for the preparation of (E)-3-acylprop-2-enoic acids ( = (E)-3-acylacrylic acids) of type II via acid catalyzed isomerization of the corresponding 3-acylprop-2-ynal acetals of type I (Scheme 1) has been found.The described reaction gives a rap

Palladium-Catalyzed Reactions of Acyl Chlorides with (1-Alkynyl)tributylstannanes. A Convenient Synthesis for 1-Alkynyl Ketones

Acyl chlorides couple with (1-alkynyl)tributylstannanes in the presence of catalytic amounts of palladium(II) or palladium(0) complexes to produce 1-alkynyl ketones in respectable yields.The couplings of isobutyryl, acetyl, benzoyl, and p-nitrobenzoyl chlorides with phenylethynyl-, (trimethylsilyl)ethynyl-, (carbomethoxy)ethynyl-, -1-propynyl>-, and (3,3-diethoxy-1-propynyl)tributylstannanes were investigated in the presence of tetrakis(triphenylphosphine)palladium(O), benzylchlorobis(triphenylphosphine)palladium(II), dichlorobis(triphenylphosphine)palladium(II), or phenyliodobis(triphenylphosphine)palladium(II).The reactions are highly selective in that only the alkynyl groups are transferred from the stannane.