5337-01-9Relevant articles and documents
Synthesis, Structure, and Excimer Formation of Cholesteric Liquid Crystals Containing Carbazolyl Groups Covalently Linked to a Cholesterol Group
Kawaguchi, Koji,Sisido, Masahiko,Imanishi, Yukio
, p. 4806 - 4811 (1988)
Cholesteryl 3-(9-carbazolyl)propanoate (9Cz-2) and cholesteryl 3-propanoate (3Cz-2) were synthesized.They did not show a cholesteric mesophase by themselves, but their 1:1 mixture with other cholesteryl arylpropanoates showed cholesteric mesophases near room temperature.The average orientations of the two types of carbazolyl groups in the quasinematic layer were determined by circular dichroism and circularly polarized fluorescence spectroscopy.Their fluorescence spectra showed a monomer fluorescence with small contribution of excimer.The intensity ratio of the excimer to monomer fluorescence of 3Cz-2 was larger than that of 9Cz-2 and reached the minimum value at the cholesteric-isotropic transition temperature.Fluorescence decay analysis indicated that monomolecular decay processes of the carbazolyl excited state are not affacted by the phase change.On the contrary, bimolecular decay processes, including excimer formation, were found to be sensitive to the phase change.Little photocurrent was observed by pulsed irradiation with a N2 laser to the cholesteric liquid crystalline mixtures containing 9Cz-2.
Cooperative Palladium/Lewis Acid-Catalyzed Transfer Hydrocyanation of Alkenes and Alkynes Using 1-Methylcyclohexa-2,5-diene-1-carbonitrile
Bhunia, Anup,Bergander, Klaus,Studer, Armido
supporting information, p. 16353 - 16359 (2018/11/25)
Catalytic transfer hydrocyanation represents a clean and safe alternative to hydrocyanation processes using toxic HCN gas. Such reactions provide access to pharmaceutically important nitrile derivatives starting with alkenes and alkynes. Herein, an efficient and practical cooperative palladium/Lewis acid-catalyzed transfer hydrocyanation of alkenes and alkynes is presented using 1-methylcyclohexa-2,5-diene-1-carbonitrile as a benign and readily available HCN source. A large set of nitrile derivatives (>50 examples) are prepared from both aliphatic and aromatic alkenes with good to excellent anti-Markovnikov selectivity. A range of aliphatic alkenes engage in selective hydrocyanation to provide the corresponding nitriles. The introduced method is useful for chain walking hydrocyanation of internal alkenes to afford terminal nitriles in good regioselectivities. This protocol is also applicable to late-stage modification of bioactive molecules.
Efficient nickel-catalyzed hydrocyanation of alkenes using acetone cyanohydrin as a safer cyano source
Nemoto, Koji,Nagafuchi, Tsuyoshi,Tominaga, Ken-ichi,Sato, Kazuhiko
, p. 3199 - 3203 (2016/07/06)
An active nickel catalyst prepared in situ from a Ni(II) compound, phosphine ligand, and zinc powder was found to be an efficient catalyst system for the hydrocyanation of various alkenes using acetone cyanohydrin as a safer cyano source. The combination of NiCl2·6H2O and 1,3-bis(diphenylphosphino)propane was the most efficient catalyst precursor in DMF. Under the optimized conditions, various styrenes, heterocyclic alkenes, and aliphatic alkenes were converted to their corresponding nitriles in excellent yields.
Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase
Dumitriu, Gina-Mirabela,Ghinet, Alina,B?cu, Elena,Rigo, Beno?t,Dubois, Jo?lle,Farce, Amaury,Belei, Dalila
, p. 3180 - 3185 (2014/06/24)
Novel phenothiazine derivatives bearing an amino acid residue were synthesized via peptide chemistry, and evaluated for their inhibitory potential on human farnesyltransferase. The phenothiazine unit proved to be an important bulky unit in the structure o
