5337-30-4Relevant articles and documents
An efficient protocol for the synthesis of β-substituted ethyl dithiocarbamates: A novel class of anti-cancer agents
Chaturvedi, Devdutt,Zaidi, Sadaf,Chaturvedi, Amit K.,Vaid, Shagun,Saxena, Ajit K.
, p. 1019 - 1025 (2017/11/10)
A novel one-pot method for the synthesis of β-substituted alkyl dithiocarbamates has been developed through die Michael addition reaction of dithiocarbamate anion to α,β-unsaturated activated olefins employing catalytic amount of benzyl trimethyl ammonium hydroxide (Triton-B). The reaction conditions are mild with extremely simple work-up procedures than the reported methods, and afford high yields (82-98%) of the desired products. All the synthesized compounds (1-16) have been evaluated for in vitro anti-cancer activity using various kinds of cancer cell lines such as lung, colon, cervical, neuroblastoma, liver and ovary employing different kinds of standard anticancer drugs such as 5-fluorouracil, mitomycin C, paclitaxel, aldriamycin, etc. using stock solution (2 × 10-2 M) prepared in DMSO and further dilution has been carried out with medium. In vitro cytotoxicity against human cancer cell lines is determined using sulphorhodamine-B assay. Out of the series of compounds evaluated, most of these compounds such as compounds 2,3,4,5,9,10,11,12,13,14,15,16 display more than 50% growth inhibition at 1 × 10-5 M concentration.
One-pot synthesis of dithiocarbamates accelerated in water
Azizi, Najmodin,Aryanasab, Fezzeh,Torkiyan, Lalleh,Ziyaei, Azim,Saidi, Mohammad Reza
, p. 3634 - 3635 (2007/10/03)
Highly efficient one-pot reactions of amines and carbon disulfide with α,β-unsaturated compounds were carried out in water under a mild and green procedure with high yields.
Synthesis of dithiourethanes using addition reactions
Kreutzkamp,Peschel
, p. 477 - 481 (2007/10/08)
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