5337-30-4

Upstream product

• 10264-39-8 diethyldithiocarbamic acid 2-cyanoethyl ester 
• 75-15-0 carbon disulfide 
• 109-89-7 diethylamine 
• 121-44-8 triethylamine 
• 79-06-1 2-propenamide 
• 392-74-5 diethyldithiocarbamate 

Relevant academic research and scientific papers

An efficient protocol for the synthesis of β-substituted ethyl dithiocarbamates: A novel class of anti-cancer agents

A novel one-pot method for the synthesis of β-substituted alkyl dithiocarbamates has been developed through die Michael addition reaction of dithiocarbamate anion to α,β-unsaturated activated olefins employing catalytic amount of benzyl trimethyl ammonium hydroxide (Triton-B). The reaction conditions are mild with extremely simple work-up procedures than the reported methods, and afford high yields (82-98%) of the desired products. All the synthesized compounds (1-16) have been evaluated for in vitro anti-cancer activity using various kinds of cancer cell lines such as lung, colon, cervical, neuroblastoma, liver and ovary employing different kinds of standard anticancer drugs such as 5-fluorouracil, mitomycin C, paclitaxel, aldriamycin, etc. using stock solution (2 × 10-2 M) prepared in DMSO and further dilution has been carried out with medium. In vitro cytotoxicity against human cancer cell lines is determined using sulphorhodamine-B assay. Out of the series of compounds evaluated, most of these compounds such as compounds 2,3,4,5,9,10,11,12,13,14,15,16 display more than 50% growth inhibition at 1 × 10-5 M concentration.

Waste-free and environment-friendly uncatalyzed synthesis of dithiocarbamates under solvent-free conditions

A mild, convenient, and practical one-pot procedure for the direct synthesis of dithiocarbamates has been developed by condensation of amines, CS2, and a Michael acceptor, under solvent-free conditions at room temperature in good to excellent yields. Georg Thieme Verlag Stuttgart.

One-pot synthesis of dithiocarbamates accelerated in water

Highly efficient one-pot reactions of amines and carbon disulfide with α,β-unsaturated compounds were carried out in water under a mild and green procedure with high yields.

Conjugated addition reaction of amine, carbon disulfide to electrophilic alkenes in the presence of anhydrous potassium phosphate

Different kinds of β-electron-withdraw group substituted ethyl dithiocarbamates (3) were prepared by the conjugated addition of an amine (1) and carbon disulfide to electrophilic alkenes (2) in the presence of anhydrous potassium phosphate under mild condition in good yields.