5337-52-0

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-chlorophenyl)-3-pyridin-2-ylprop-2-en-1-one is used as a pharmaceutical intermediate for the development of new drugs due to its potential biological activities and chemical properties.
Used in Chemical Synthesis:
(2E)-1-(4-chlorophenyl)-3-pyridin-2-ylprop-2-en-1-one is used as a key building block in the synthesis of various heterocyclic compounds, which are important in the field of organic chemistry.
Used in Anti-Inflammatory Applications:
(2E)-1-(4-chlorophenyl)-3-pyridin-2-ylprop-2-en-1-one is utilized for its anti-inflammatory properties, making it a potential candidate for the treatment of inflammation-related conditions.
Used in Antimicrobial Applications:
(2E)-1-(4-chlorophenyl)-3-pyridin-2-ylprop-2-en-1-one is also used for its antimicrobial properties, indicating its potential use in combating microbial infections.
Used in Chemical Product Manufacturing:
(2E)-1-(4-chlorophenyl)-3-pyridin-2-ylprop-2-en-1-one is employed in the manufacturing of various chemical products, highlighting its versatility and importance in the chemical industry.

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 132577-36-7 1-[3-(4-Chloro-phenyl)-5-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl]-ethanone 
• 1091617-17-2 4-(4-chlorophenyl)-6-(pyridin-2-yl)pyrimidin-2-amine 

Relevant academic research and scientific papers

Ultrasound-mediated synthesis, biological evaluation, docking and in vivo acute oral toxicity study of novel indolin-2-one coupled pyrimidine derivatives

The work reports ultrasound-mediated greener synthesis of 11 novel 3-(4-(4-chlorophenyl)-6-(substituted phenyl/heteryl)pyrimidin-2-ylimino)indolin-2-one (7a–7k) derivatives. The synthesized derivatives were evaluated for their in vitro anticancer activity against a panel of selected human cancer cell lines of breast (MCF-7), cervix (HeLa), prostate (PC-3) and lung (A-549). Among the tested compounds, 7b exhibited most promising in vitro anticancer activity against HeLa, PC-3 and A-549 with GI50 value 15.38, 19.67 and 4.37?μM, respectively. The compounds (7a–7k) were also screened for induction of apoptosis and morphological changes in cancer cells at their GI50 concentration. The treatment of HeLa, PC-3 and A549 cancer cells with 7b and treatment of MCF-7 cancer cells with 7h showed apoptosis and morphological changes such as cell shrinkage, cell wall deformation and reduced number of viable cells. The compound 7b has shown almost 5.00 times more selectivity for PC-3 cancer cell lines in comparison to the RWPE-1 normal prostate epithelial cells. Molecular docking study has been carried out, which replicates results of biological activity in cases of initial hits 7b, 7c and 7d, suggesting that these compounds have a potential to become lead molecules in the drug discovery process. In silico ADMET study was performed for predicting pharmacokinetic properties and toxicity profile of the synthesized compounds and expressed good oral drug-like behaviour. An in vivo acute oral toxicity study was performed using Swiss albino mice for the most active compounds 7b and 7c, and results indicate that the compounds are non-toxic in nature.

Organic base-mediated condensation of pyridinecarboxaldehydes to azachalcones

A DBU-mediated aldol condensation-dehydration sequence has been used to prepare a series of synthetically important substituted 2- and 3-azachalcones. Michael products that typically accompany this sequence with inorganic bases were not observed in this p

Synthesis of 3-Cyano-2-methylpyridines Substituted with Heteroaromatics

A series of title compounds were easily prepared by the sonication of α,β-unsaturated carbonyl compound in acetonitril in the presence of potassium t-butoxide.