53372-36-4Relevant academic research and scientific papers
Synthesis of 1,3-Aminoalcohols and Spirocyclic Azetidines via Tandem Hydroxymethylation and Aminomethylation Reaction of β-Keto Phosphonates with N-Nosyl- O-(2-bromoethyl)hydroxylamine
Chen, Hongbing,Gao, Min,Gong, Xiangnan,Hu, Lin,Wu, Binyu
, p. 4152 - 4157 (2021)
An unprecedented tandem α-hydroxymethylation and α-aminomethylation reaction of aromatic cyclic β-keto phosphonates with N-nosyl-O-(2-bromoethyl)hydroxylamine in the presence of DBU base has been developed, affording a range of 1,3-aminoalcohols in good y
Hydrophosphonylation of Alkynes with Trialkyl Phosphites Catalyzed by Nickel
Islas, Rosa E.,García, Juventino J.
, p. 4125 - 4131 (2017/10/09)
The use of simple and inexpensive NiCl2?6 H2O as a catalyst precursor for C?P bond formation in the presence of commercially available trialkyl phosphites (P(OR)3, R=Et, iPr, Bu, SiMe3) along with several alkynes is presented. Control experiments showed the in situ formation of (RO)2P(O)H as the species that undergo the addition into the C≡C bond at the alkynes to yield the product of P?H addition. The hydrophosphonylation of diphenylacetylene with P(OEt)3, P(OiPr)3, and P(OSiMe3)3 proceeds in high yields (>92 %) without the need of a specific solvent or ligand. This method is useful for the preparation of organophosphonates for both phenylacetylene as a terminal alkyne model and internal alkynes in yields that range from good to modest.
A new and facile synthetic route to 1-alkyl-2-oxopropylphosphonates: 1 alkylation with subsequent ozonolysis of 2-methyl allylic phosphonates
Gil, Jun Mo,Park, Kwang Young,Hah, Jung Hwan,Oh, Dong Young
, p. 3601 - 3607 (2007/10/03)
Alkylation of the 2-methyl allylic phosphonates is performed by treatment with n-BuLi, followed by addition of alkyl halides. The 1-alkyl-2- oxopropylphosphonates are obtained by the ozonolysis of the corresponding allylic phosphonates.
