53379-65-0Relevant academic research and scientific papers
Chiral synthesis of an α-tetrasubstituted proline derivative
Humphreys, Eric R.,Hong, Jun-Bae,Green, Keena L.
, p. 2256 - 2264 (2011)
Triple reuptake inhibitors (TRIs) have been identified as possible alternative treatments for central nervous system disorders. A practical synthesis was investigated to access a potent TRI, (4-amino-3-chloro-phenyl)- ((S)-2-isobutyl-pyrrlidin-2-yl)- methanone (1), starting from alkylation of D-proline. Improved routes to key intermediates are discussed and demonstrated by an expedient multigram production of 1. Copyright
