1879-55-6Relevant academic research and scientific papers
Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes
Cruz, Daniel A.,Sinka, Victoria,De Armas, Pedro,Steingruber, Hugo Sebastian,Fernández, Israel,Martín, Víctor S.,Miranda, Pedro O.,Padrón, Juan I.
supporting information, p. 6105 - 6109 (2021/08/18)
A new method that allows the complete control of the regioselectivity of the hydrobromination reaction of alkenes is described. Herein, we report a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of parts per million amounts of the Cu(I) species and the formation of the Markovnikov product occurs in the presence of 30 mol % iron(II) bromide. Density functional theory calculations combined with Fukui's radical susceptibilities support the obtained results.
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
Chen, Li,Zhang, Yaling,Liu, Juan,Wang, Weijia,Li, Xiabing,Zhao, Lijun,Wang, Wei,Li, Baolin
, p. 689 - 697 (2017/07/17)
A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were designed, synthesized and evaluated for biological activities in vitro. Most compounds exhibited highly antiproliferative activities against all tested tumor cell lines in
Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions
Rong, Guangwei,Liu, Defu,Lu, Linhua,Yan, Hong,Zheng, Yang,Chen, Jie,Mao, Jincheng
, p. 5033 - 5037 (2014/12/10)
It is the first time to find that iron-catalyzed decarboxylative methylation of α,β-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-t
Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions
Rong, Guangwei,Liu, Defu,Lu, Linhua,Yan, Hong,Zheng, Yang,Chen, Jie,Mao, Jincheng
, p. 5033 - 5037 (2014/07/08)
It is the first time to find that iron-catalyzed decarboxylative methylation of α,β-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-t
SINGLE-STEP PROCESS FOR THE PREPARATION OF ARYL OLEFINS
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Page/Page column 16-17, (2014/05/24)
The present invention relates to the single-step process for the synthesis of aryl olefin compounds of Formula (1) by reacting aryl aldehydes with alkyl aldehydes in presence of malononitrile and acid or base or salt, optionally in presence of solvent.
Efficient stille cross-coupling reaction catalysed by the Pd(OAc) 2/orotic acid catalytic system
Zhang, Hong-Ping,Li, Xiao-Fang,Li, Hong-Yan
, p. 219 - 222 (2013/07/05)
An efficient Pd(OAc)2/orotic acid catalytic system has been developed for the Stille cross-coupling reaction. In the presence of Pd(OAc)2 and orotic acid, various halides including aryl iodides, aryl bromides, vinyl bromides, and aryl chlorides were coupled efficiently with aryl- and vinyltin compounds to afford the corresponding biaryls and stilbenes. The high catalytic efficacy of Pd(OAc)2/orotic acid has also been demonstrated.
Efficient pyrimidone-promoted palladium-catalyzed Suzuki-Miyaura cross-coupling reaction
Zhang, Hong-Ping,Dai, You-Zhi,Zhou, Xi,Yu, Huang
supporting information; experimental part, p. 1221 - 1224 (2012/06/04)
An efficient Pd(OAc)2/orotic acid catalytic system has been developed for Suzuki-Miyaura cross-coupling reaction of halides with aryl- and vinylboronic acids. The use of pyrimidone as ligand makes this method useful and attractive for the synthesis of stilbenes and derivative compounds. An attractive feature of this method is the tolerance of functional groups in both substrates. Georg Thieme Verlag Stuttgart · New York.
Unexpected Selectivity in the Alkylation of Polyazamacrocycles
Kruper, William J.,Rudolf, Philip R.,Langhoff, Charles A.
, p. 3869 - 3876 (2007/10/02)
Reaction of equivalent amounts of free base polyazamacrocycles with an alkyl halide in a nonpolar, aprotic solvent affords the mono-N-alkylation product as its monohydrohalide salt in high yield with excellent selectivity.This unexpected selectivity has been explained in terms of the high affinity of the alkylated product for a single proton which attenuates the nucleophilicity of the remaining nitrogen atoms.Selectivity is dependent upon a number of factors including macrocycle ring size, solvent polarity, and the steric nature of the electrophile.The approach has been allowed for a short, convergent route to bifunctional lanthanide chelators which are useful in therapeutic applications.
THE REACTION OF BENZYLTRIPHENYLARSONIUM YLIDES WITH ALDEHYDES. A NOTE ABOUT THE MECHANISM OF THE WITTIG REACTION.
Broos, Rene,Anteunis, Marc J. O.
, p. 271 - 280 (2007/10/02)
The products and stereochemistry of the reaction of the benzyltriphenyl arsonium ylide with benzaldehyde and acetaldehyde both in the presence of lithium salts and under salt-free conditions are studied by 1H NMR at 360 MHz.The stereochemistry is discussed in view of recent developments in the mechanistic interpretation of the Wittig and Johnson-Corey-Chaykovsky reaction.
NEW PREPARATIONS OF p-NITROPHENYLCYCLOPROPANE
Broos, R.,Anteunis, M. J. O.
, p. 135 - 138 (2007/10/02)
The preparation of p-nitrocyclopropylbenzene by reaction of dimethyloxosulfonium methylide with p-nitrostyrene or p-nitrobenzyl iodide (bromide) in 67 and 37 percent yield respectively is reported.
