53399-22-7Relevant academic research and scientific papers
Studies on Synthetic Methods for 5-Amino-4(3H)-pyrimidones. I. A Novel Ring Expansion Reaction of 4-Aminoantipyrines to 5-Amino-4(3H)-pyrimidones
Udea, Taisei,Oda, Noriichi,Ito, Isoo
, p. 2144 - 2147 (2007/10/02)
4-Anilino(or amino)antipyrines (Ia, b) were transformed into 5-anilino(or amino)-4(3H)-pyrimidones (IIa, b) in the presence of bases such as sodium hydride, sodium amide, sodium hydroxide, or sodium ethoxide in refluxing xylene.Treatment of IIa with hydrazine hydrate gave 4-anilino-5-hydroxy-3-methyl pyrazole (V).However, the reaction of IIb with hydrazine hydrate gave 3,5-diamino-6-methyl-4(3H)-pyrimidone (VI) and 4-(5-oxo-3-methyl-pyrazolinyliden)amino-5-hydroxy-3-methyl pyrazole (VII).
