1801-18-9

Upstream product

• 102-01-2 N-phenylacetoacetamide 
• 626-34-6 ethyl aminocrotonate 
• 62-53-3 aniline 
• 7664-41-7 ammonia 

Downstream Products

• 111961-65-0 3-amino-butyric acid anilide 
• 143755-49-1 ethyl 2,6-dimethyl-4-phenyl-5-(phenylcarbamoyl)-1,4-dihydropyridine-3-carboxylate 
• 64-17-5 ethanol 
• 105707-05-9 5-Benzoylamino-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide 
• 81038-81-5 2-methyl-2-(N-phenylcarbamoyl)methyl-1,2,3,4-tetrahydroquinazolin-4-one 
• 78944-54-4 (3,6-Dimethyl-1,5-dioxo-4-aza-2-heptenylamino)benzene 
• 78944-58-8 (3,7-Dimethyl-1,5-dioxo-4-aza-2-octenylamino)benzene 
• 102-01-2 N-phenylacetoacetamide 
• 858848-60-9 4-hydroxy-2-methyl-thiophene-3-carboxylic acid anilide 
• 43154-92-3 3-methyl-N,1,5-triphenyl-1H-pyrazole-4-carboxamide 
• 869792-42-7 3-[N-(tert-butoxycarbonyl)amino]-N-phenylbutanamide 
• 95155-03-6 3-[3,5-Dioxo-1-phenyl-pyrazolidin-(4Z)-ylidene]-N-phenyl-butyramide 
• 108137-71-9 (Z)-3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-but-2-enoic acid phenylamide 
• 32363-53-4 2,6-dimethyl-3-phenyl-4(3H)-pyrimidinone 

Relevant academic research and scientific papers

Lewis Acid-Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

A direct and single-step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid-promoted [3+3] annulation between 3-ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope. (Figure presented.).

Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2-alkyl migration of enamino amides for synthesis of pyrrolin-4-ones

A novel Cu(TFA)2-catalyzed oxidative tandem cyclization/1,2- alkyl migration of readily available enamino amides for the synthesis of pyrrolin-4-ones has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of substituted pyrrolin-4-ones in high yields under mild conditions.

Detection and elimination of product inhibition from the asymmetric catalytic hydrogenation of enamines

(Chemical Equation Presented) The catalytic asymmetric hydrogenation of enamine amides and esters with catalyst Rh-1a, prepared from ferrocenyl based ligand 1a or 1b and [(COD)RhCl]2, has been shown through kinetic studies to suffer from product inhibition. Enamine ester substrates have also been shown to be incompatible with the amine products of the reaction in methanol. In situ protection of the amine products with di-tert-butyl dicarbonate eliminates functional group incompatibility of ester substrates and eliminates product inhibition in the reaction.

Dihydropyridine anti-allergic and antiinflammatory agents

Certain 4-aryl-5-carbamoyl-1,4-dihydropyridines useful in the treatment of allergic and inflammatory conditions in mammals.

Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones

6-Substituted 3-aryl-2-methyl-4(3H)-pyrimidones (III) have been prepared by the reaction of N-arylacetamidines (II) with various diplorophiles like ethyl propiolate, ethyl tetrolate and ethyl phenylpropiolate.The structure of the products has been confirm

Juvenile Hormon-like Substances : Part II - Synthesis of (3,7-Dimethyl-4-aza-2-octenylamino)benzene and (3,6-Dimethyl-4-aza-2-heptenylamino)-benzene

Condensation of ethyl 3-aminocrotonate with aniline furnishes β-aminocrotonanilide (I) which reacts with isovaleric acid or its chloride to give (3,7-dimethyl-1,5-dioxo-4-aza-2-octenylamino)benzene (II).LAH reduction of II affords (3,7-dimethyl-4-aza-2-oc