65765-92-6

Upstream product

• 84321-35-7 7-oxo-6-ohenyl-6H-isoselenazolo<4,3-d>pyrimidine 
• 138711-45-2 6-Methyl-5-(p-nitrobenzamido)-3-phenylpyrimidin-4(3H)-one 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 64-17-5 ethanol 
• 89966-52-9 5-(chloroacetylamino)-6-methyl-3-phenyl-4(3H)-pyrimidinone 

Downstream Products

• 89966-49-4 5-acetamido-6-methyl-3-phenyl-4(3H)-pyrimidinone 
• 89966-65-4 5-benzylideneamino-6-methyl-3-phenyl-4(3H)-pyrimidinone 
• 89966-66-5 5-(p-methoxybenzylideneamino)-6-methyl-3-phenyl-4(3H)-pyrimidinone 
• 138944-37-3 2-isopropoxy-5-methyl-N-phenyl-1H-imidazole-4-carboxamide 
• 138711-42-9 5-Acrylamido-6-methyl-3-phenylpyrimidin-4(3H)-one 
• 138944-38-4 2-(sec-butoxy)-5-methyl-N-phenyl-1H-imidazole-4-carboxamide 
• 89966-50-7 5-(α-bromopropionamido)-6-methyl-3-phenyl-4(3H)-pyrimidinone 
• 138944-33-9 2-methoxy-5-methyl-N-phenyl-1H-imidazole-4-carboxamide 
• 142599-06-2 2-(formamido)-2-methoxy-3-oxobutananilide 
• 142599-07-3 3-(N-chloroimino)-2-(formamido)-2-methoxybutananilide 
• 138944-35-1 5-methyl-N-phenyl-2-propoxy-1H-imidazole-4-carboxamide 
• 89966-54-1 5-dimethylamino-6-methyl-3-phenyl-4(3H)-pyrimidinone 
• 138711-41-8 5-Formamido-6-methyl-3-phenylpyrimidin-4(3H)-one 
• 138944-34-0 2-ethoxy-5-methyl-N-phenyl-1H-imidazole-4-carboxamide 

Relevant academic research and scientific papers

Synthesis of 1H-Imidazoles by the Simple Ring Transformation of 5-Acylaminouracils and 5-Acylaminopyrimidin-4(3H)-ones

1,2-Disubstituted 4-alkylcarbamoyl-5-methyl-1H-imidazoles and 2-substituted 5-methyl-4-phenylcarbamoyl-1H-imidazoles were synthesized from 5-acylamino-6-methyluracils and 5-acylamino-6-methyl-3-phenylpyrimidin-4(3H)-ones by treatment with sodium hydroxide in ethanol.In the case of 5-acylaminopyrimidinones which possess an olefinic group in the acylamino group, 2-ethoxyethyl (or 2-ethoxypropyl)-5-methyl-4-phenylcarbamoyl-1H-imidazoles were prepared as major products and the corresponding 2-alkenyl-1H-imidazoles were only minor products.Compounds which contain an aryl function in their acylamino group gave glycine anilides as byproducts.

AN UNUSUAL TRANSFORMATION OF 5-AMINO-6-METHYL-3-PHENYL-4(3H)-PYRIMIDONE WITH SELENIUM DIOXIDE: X-RAY CRYSTAL STRUCTURE OF 3-PHENYLCARBAMOYL-4-METHYL-1,2,5-SELENADIAZOLE

The reaction of 5-amino-6-methyl-3-phenyl-4(3H)-pyrimidone (1) with selenium dioxide in dioxane gave the unusual products: 6-phenyl-7(6H)-isoselenazolopyrimidone (2) and 3-phenylcarbamoyl-4-methyl-1,2,5-selenadiazole (3) in the ratio 1:2.KEYWORDS -

Studies on Synthetic Methods for 5-Amino-4(3H)-pyrimidones. I. A Novel Ring Expansion Reaction of 4-Aminoantipyrines to 5-Amino-4(3H)-pyrimidones

4-Anilino(or amino)antipyrines (Ia, b) were transformed into 5-anilino(or amino)-4(3H)-pyrimidones (IIa, b) in the presence of bases such as sodium hydride, sodium amide, sodium hydroxide, or sodium ethoxide in refluxing xylene.Treatment of IIa with hydrazine hydrate gave 4-anilino-5-hydroxy-3-methyl pyrazole (V).However, the reaction of IIb with hydrazine hydrate gave 3,5-diamino-6-methyl-4(3H)-pyrimidone (VI) and 4-(5-oxo-3-methyl-pyrazolinyliden)amino-5-hydroxy-3-methyl pyrazole (VII).