5343-35-1

Usage

Uses

Used in Pharmaceutical Industry:
1-Amino-pentan-2-ol is used as a phenylethanolamine methyltransferase (PEMT) substrate for the synthesis of various pharmaceutical compounds. PEMT is an enzyme that plays a vital role in the biosynthesis of neurotransmitters and hormones, such as dopamine, norepinephrine, and epinephrine. By acting as a substrate for this enzyme, 1-Amino-pentan-2-ol contributes to the production of these essential molecules, which are crucial for maintaining proper brain function and regulating various physiological processes.
Used in Drug Design and Development:
1-Amino-pentan-2-ol is also utilized in the field of drug design and development, particularly for creating computer-aided ligandand receptor-based drugs. Its unique molecular structure allows it to be used as a starting point or a key intermediate in the synthesis of novel drug candidates. By employing computer-aided drug design techniques, researchers can identify and optimize the interactions between 1-Amino-pentan-2-ol and its target receptors, leading to the development of more effective and selective therapeutic agents.

InChI:InChI=1/C5H13NO/c1-2-3-5(7)4-6/h5,7H,2-4,6H2,1H3

Upstream product

• 1436-34-6 1,2-Epoxyhexane 
• 2224-37-5 1-nitropentan-2-ol 
• 64-17-5 ethanol 
• 85149-05-9 1-nitro-pent-3-en-2-ol 
• 74-90-8 hydrogen cyanide 
• 123-72-8 butyraldehyde 

Relevant academic research and scientific papers

2-OXO-1,3-OXAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES

The present invention relates to 2-oxo-1,3-oxazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Chiral-Organotin-Catalyzed Kinetic Resolution of Vicinal Amino Alcohols

A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin compound with 3,4,5-trifluorophenyl groups at the 3,3′-positions of the binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl- and alkyl-substituted amino alcohols and a variety of other substrates, affording the corresponding products in high enantioselectivity and with s factors up to >500.

JNK INHIBITOR

A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is -O-, -N=, -NR3- or -CHR3-, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.