1-Aminopentan-2-ol

Base Information

• Chemical Name: 1-Aminopentan-2-ol
• CAS No.: 5343-35-1
• Molecular Formula: C5H13 N O
• Molecular Weight: 103.16
• Hs Code.: 2922199090
• NSC Number: 445
• DSSTox Substance ID: DTXSID80275931,DTXSID501316108
• Nikkaji Number: J49.942K
• Mol file: 5343-35-1.mol

Synonyms:1-aminopentan-2-ol;5343-35-1;1-Amino-pentan-2-ol;1-Amino-2-pentanol;2-Pentanol, 1-amino-;USAF CS-3;NSC 445;189769-47-9;Butanol, (aminomethyl)- (9CI);NSC445;propylethanolamine;WLN: ZYQ4;SCHEMBL24568;DTXSID80275931;NSC-445;DTXSID501316108;MFCD01709192;AKOS009469240;LS-101870;CS-0161816;EN300-75514;E76713;Z419084742

Chemical Property of 1-Aminopentan-2-ol

Chemical Property:

• Vapor Pressure: 0.108mmHg at 25°C
• Boiling Point: 195.6°C at 760 mmHg
• PKA: 12.92±0.35(Predicted)
• Flash Point: 72.1°C
• PSA: 46.25000
• Density: 0.915g/cm³
• LogP: 0.80640
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 103.099714038
• Heavy Atom Count: 7
• Complexity: 39.1

Purity/Quality:

99%min ^*data from raw suppliers

1-Aminopentan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(CN)O
• Uses: 1-Aminopentan-2-ol (cas# 5343-35-1) is a useful as a phenylethanolamine methyltransferase substrate and for designing computer-aided ligand- and receptor-based drugs.

Technology Process of 1-Aminopentan-2-ol

There total 7 articles about 1-Aminopentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,2-Epoxyhexane (1436-34-6) → 1-amino-2-hydroxy-pentane (5343-35-1)

Guidance literature:

With ammonia; In water; at 20 ℃; for 18h;

Reference yield:

1-nitropentan-2-ol (2224-37-5) → 1-amino-2-hydroxy-pentane (5343-35-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 50 ℃; for 1h; under 37503.8 Torr;

Reference yield:

1-nitro-pent-3-en-2-ol (85149-05-9) → 1-amino-2-hydroxy-pentane (5343-35-1)

Guidance literature:

With ethanol; nickel; at 35 - 40 ℃; under 58840.6 Torr; Hydrogenation;

DOI:10.1039/jr9480001907

upstream raw materials:

1-nitro-pent-3-en-2-ol

hydrogen cyanide

butyraldehyde

ethanol

Refernces

• 1、 Yang, Hui,Zheng, Wen-Hua. "Chiral-Organotin-Catalyzed Kinetic Resolution of Vicinal Amino Alcohols". supporting information. p. 16177 - 16180. Retrieved 2019/11/03.