5344-44-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-5-nitro-aniline is used as a key intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows for the development of new drugs with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Pesticide Industry:
In the agricultural sector, 3-chloro-5-nitro-aniline serves as an intermediate in the production of certain pesticides. Its incorporation into these compounds aids in the control of pests, thereby supporting crop protection and food security.
Used in Dye Industry:
3-Chloro-5-nitro-aniline is also utilized in the dye industry, where it acts as a precursor for the creation of different types of dyes. These dyes find applications in various fields such as textiles, plastics, and printing inks.
Used as a Reagent in Organic Synthesis:
Beyond its role as an intermediate, 3-chloro-5-nitro-aniline is employed as a reagent in organic synthesis. It facilitates various chemical reactions, enabling the production of a range of organic compounds for diverse applications.
Used as a Starting Material for Other Chemical Compounds:
3-Chloro-5-nitro-aniline functions as a starting material for the production of other chemical compounds, highlighting its importance in the broader scope of chemical manufacturing and research.
Safety Precautions:
Given the potential toxicity of 3-chloro-5-nitro-aniline, it is crucial to handle and store 3-chloro-5-nitro-aniline with appropriate safety measures. Its use must adhere to established safety regulations and guidelines to mitigate any risks associated with its handling or exposure.

InChI:InChI=1/C6H5ClN2O2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H,8H2

Upstream product

• 618-86-0 1-chloro-3,5-dinitrobenzene 
• 64-17-5 ethanol 
• 7783-06-4 hydrogen sulfide 
• 7664-41-7 ammonia 
• 618-87-1 3, 5-dinitroaniline 
• 99-65-0 meta-dinitrobenzene 

Downstream Products

• 618-62-2 3,5-dichloro-1-nitrobenzene 
• 5540-64-7 Nonanoic acid (3-chloro-5-nitro-phenyl)-amide 
• 185500-57-6 1-Chloro-3-isothiocyanato-5-nitro-benzene 
• 1261790-98-0 C₇H₃ClN₂O₃ 
• 879614-87-6 tert-butyl N-tert-butoxycarbonyl-N-(2-chloro-5-nitrophenyl)carbamate 
• 1309831-81-9 1-(5-Amino-3-chlorophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 1309831-78-4 1-(3-Chloro-5-nitrophenyl)-1H-tetrazol-5(4H)-one 
• 1309831-79-5 1-(3-Chloro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one 
• 6590-93-8 3,5-dichlorophenylisothiocyanate 
• 626-43-7 3,5-Dichloroaniline 

Relevant academic research and scientific papers

Novel Anthranilic Diamide Scaffolds Containing N-Substituted Phenylpyrazole as Potential Ryanodine Receptor Activators

To discover potent insecticides targeting ryanodine receptors (RyRs), a series of novel anthranilic diamides analogues (12a-12u) containing N-substituted phenylpyrazole were designed and synthesized. These compounds were characterized by 1H NMR, 13C NMR, and HRMS, and the structure of compound 12u was confirmed by X-ray diffraction. Their insecticidal activities indicated that these compounds displayed moderate to excellent activities. In particular, 12i showed 100 and 37% larvicidal activities against oriental armyworm (Mythimna separata) at 0.25 and 0.05 mg L-1, equivalent to that of chlorantraniliprole (100%, 0.25 mg L-1; and 33%, 0.05 mg L-1). The activity of 12i against diamondback moth (Plutella xylostella) was 95% at 0.05 mg L-1, whereas the control was 100% at 0.05 mg L-1. The calcium-imaging technique experiment results showed that the effects of 12i on the intracellular calcium ion concentration ([Ca2+]i) in neurons were concentration-dependent. After the central neurons of Helicoverpa armigera were dyed by loading with fluo-5N and treated with 12i, the free calcium released in endoplasmic reticulum indicated the target of compound 12i is RyRs or IP3Rs. The activation of RyRs by natural ryanodine completely blocked the calcium release induced by 12i, which indicated that RyRs in the central neurons of H. armigera third-instar larvae is the possible target of compound 12i.

SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Efficient and selective room-temperature gold-catalyzed reduction of nitro compounds with CO and H2O as the hydrogen source

[Chemical equation presented] Taking hydrogen from water: Gold catalysis enabled the selective reduction of nitro compounds under very mild conditions with a combination of H2O and CO as the reductant (see scheme). This environmentally friendly reaction proceeded in high yield and with high chemoselectivity in the presence of a wide range of functional groups

Small molecules useful in the treatment of inflammatory disease

Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 5-(R)-(4-bromobenzyl)-3-(3-chloro-5-nitrophenyl)-5-methylimidazoline-2,4-dione; and, 5-(R)-(4-bromobenzyl