19628-76-3

Usage

Uses

Used in Organic Synthesis:
3,5-Dimethyl-4-nitrosophenol is used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to be a versatile building block in the creation of a wide range of molecules with different properties and applications.
Used in Pharmaceutical Synthesis:
3,5-Dimethyl-4-nitrosophenol is used as an intermediate in the synthesis of 4-Hydroxy Xylazine, which is a major metabolite of Xylazine (X748000). Xylazine is a veterinary sedative and analgesic drug used in animals, and its metabolite, 4-Hydroxy Xylazine, has potential applications in the pharmaceutical industry for the development of new drugs with similar or improved properties.
Used in Chemical Research:
As a compound with distinct chemical properties, 3,5-Dimethyl-4-nitrosophenol can be utilized in chemical research to study various reaction mechanisms, explore new synthetic routes, and develop novel compounds with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C8H9NO2/c1-5-3-7(10)4-6(2)8(5)9-11/h3-4,10H,1-2H3

Upstream product

• 108-68-9 3,5-Dimethylphenol 
• 67-64-1 acetone 
• 29917-12-2 Isonitrosoacetylacetone 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 

Downstream Products

• 39942-41-1 4-hydroxylidocaine 
• 857570-22-0 N-Chloroacetyl-3,5-dimethyl-4-aminophenol 
• 33098-86-1 5-acetoxy-2-acetylamino-1,3-dimethyl-benzene 
• 223133-18-4 2-chloro-3,5-dimethylbenzene-1,4-diol 
• 5344-97-8 3,5-dimethyl-4-nitrophenol 
• 223131-84-8 5-{4-[6-(2-chloro-4-hydroxy-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl}thiazolidine-2,4-dione 
• 223133-27-5 t-butyl N-[5-(2-chloro-4-methoxymethoxy-3,5-dimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate 
• 223133-19-5 3-chloro-2,6-dimethyl-4-pivaloyloxyphenol 
• 223133-20-8 2-chloro-4-methoxymethoxy-3,5-dimethylphenol 
• 1313574-65-0 6,10-dimethyl-8-oxo-1,2,3,4-tetraphenylspiro[4.5]deca-1,3,6,9-tetraene 
• 3096-70-6 3,5-dimethyl-4-aminophenol 

Relevant academic research and scientific papers

Pd-catalyzed [2+2+1] coupling of alkynes and arenes: Phenol diazonium salts as mechanistic trapdoors

Alkynes and phenol diazonium salts undergo a Pd-catalyzed [2+2+1] cyclization reaction to spiro[4,5]decatetraene-7-ones. This structure was confirmed for one example by X-ray single-crystal structure analysis. The reaction is believed to proceed through oxidative addition of the phenol diazonium cation to Pd0, subsequent insertion of two alkynes, followed by irreversible spirocyclization. Copyright

BENZYLOXYANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS

The present invention relates to benzyloxyanilide derivatives having the following structural formula: I The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modul

Amidinoureas substituted in both the urea and amidino nitrogen positions

A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.

Substituted phenyl amidinoureas

This invention relates to a method of lowering blood pressure in humans and mammals using 2,6-disubstituted phenyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, haloacyloxy, or acyloxy group and to novel 2,6-disubstituted phenyl amidinoureas which possess pharmaceutical properties, including blood pressure lowering activity.

CYCLIZATION OF HYDROXYIMINO-β-DICARBONYL COMPOUNDS WITH KETONES UNDER THE INFLUENCE OF ALKALI-METAL ALKOXIDES

Investigation of the condensation of hydroxyimino-β-dicarbonyl compounds with acetone in the presence of sodium ethoxide by a spectrophotometric methods showed that the accumulation rate of 3,5-dimethyl-2-nitrosophenol in the reaction of hydroxyiminoacetylacetone with acetone increases with increase in the sodium ethoxide concentration.In the transition to arylated hydroxyimino-β-diketones p-nitrosophenols are formed exclusively and the reaction rate decreases, but increase in the electron-withdrawing characteristics of the substituent in the benzene ring of the hydroxyimino-β-dicarbonyl compound leads to an increase in the cyclization rate.For the case of the condensation of hydroxyiminoacetylacetone with acetone and methyl ethyl ketone an increase was found in the ratio of the para and ortho isomers of the nitrosophenols with decrease in the radius of the alkali metal, with substitution of potassium ethoxide by the alkoxides of tertiary alcohols, and with the use of solvents not containing hydroxyl group ( DMSO ).On the basis of the obtained data an improved preparative method was developed for the synthesis of p-nitrosophenols.A series of 2,3,5-trialkylnitrosophenols and previously unobtainable 3,5-di(aryl)heterylnitrosophenols were obtained.