53442-08-3

Upstream product

• 100-52-7 benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 698-16-8 benzohydroximoyl chloride 
• 932-90-1 Benzaldoxime 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 34918-76-8 N-(4-chlorophenyl)benzimidoyl chloride 
• 7035-69-0 N-(4-chlorophenyl)benzamidine 

Downstream Products

• 15952-20-2 6-chloro-2-phenylbenzo[d]oxazole 
• 63105-05-5 3-(4-chloro-phenyl)-4-phenyl-3H-[1,2,3,5]oxathiadiazole 2-oxide 
• 1967-26-6 N-(4-chlorophenyl)-N'-phenylurea 
• 109073-48-5 4-(4-chlorophenyl)-3-phenyl-1,2,4-oxadiazol-5(4H)-one 
• 4926-65-2 5-chloro-2-phenyl-1H-benzimidazole 

Relevant academic research and scientific papers

13C NMR substituent-induced chemical shifts in 4-(substituted phenyl)-3-phenyl-1,2,4-oxadiazol-5(4H)-ones (thiones)

In the present, study mostly novel ten 4-(substituted phenyl)-3-phenyl-1,2,4-oxadiazol-5(4H)-ones and ten 4-(substituted phenyl)-3-phenyl-1,2,4-oxadiazol-5(4H)-thiones were synthesized. These oxadiazole derivatives were characterized by IR, 1H

Synthesis and substituent effect study on 13C NMR chemical shifts of 4-(substitue-phenyl)-6-methyl-3-phenyl-4H-1,2,4-oxadiazin-5(6H)-one

The twelve novel 4-(substituted-phenyl)-6-methyl-3-phenyl-4H-1,2,4-oxadiazin-5(6H)-one derivatives were synthesized by the reactions of N-Substituted-phenyl-benzamide oximes with 2-bromopropionyl chloride. The synthesized 1,2,4-oxadiazin-5-one derivatives

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction

A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.