2866-82-2

Basic information

• Product Name: 4'-CHLOROBENZANILIDE, 98%
• Synonyms: Benzanilide,4'-chloro- (6CI,7CI,8CI); 4'-Chlorobenzanilide; N-(4-Chlorophenyl)benzamide;N-(p-Chlorophenyl)benzamide; N-Benzoyl-4-chloroaniline; NSC 83620
• CAS NO: 2866-82-2
• Molecular Formula: C₁₃H₁₀ClNO
• Molecular Weight: 231.68
• Mol File: 2866-82-2.mol
• Article Data: 206

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-CHLOROBENZANILIDE, 98%(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLOROBENZANILIDE, 98%(2866-82-2)
• EPA Substance Registry System: 4'-CHLOROBENZANILIDE, 98%(2866-82-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 2866-82-2(Hazardous Substances Data)

Usage

General Description

4'-Chlorobenzanilide, with a purity of 98%, is a chemical compound used in various industrial applications. It is a white to off-white crystalline solid with a molecular formula of C13H10ClNO and a molecular weight of 229.68 g/mol. 4'-CHLOROBENZANILIDE, 98% is commonly used as an intermediate in the production of pharmaceuticals, dyes, and other organic compounds. It is also utilized as a precursor in the synthesis of other chemicals and as a starting material for organic reactions. 4'-Chlorobenzanilide is handled and stored under strict safety measures due to its potential hazards if mishandled. Overall, it is an important chemical with versatile uses in the chemical and pharmaceutical industries.

Upstream product

• 34918-76-8 N-(4-Chloro-phenyl)-benzimidoyl chloride 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 304-88-1 N-phenylbenzohydroxamic acid 
• 884-09-3 phenyl thiobenzoate 
• 106-47-8 4-chloro-aniline 
• 10371-42-3 S-(4-methylphenyl) thiobenzoate 
• 4906-35-8 S-(4-chlorophenyl) benzothioate 
• 1219-32-5 S-4-nitrophenyl thiobenzoate 
• 7647-01-0 hydrogenchloride 
• 93-98-1 N-phenyl benzoyl amide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 64-19-7 acetic acid 
• 93-97-0 benzoic acid anhydride 
• 3296-05-7 1-azido-4-chlorobenzene 

Downstream Products

• 1255640-10-8 C₁₈H₁₆ClNO 
• 89-63-4 4-Chloro-2-nitroaniline 
• 106-47-8 4-chloro-aniline 
• 100-51-6 benzyl alcohol 
• 60011-73-6 N-benzo-p-chloranilid 
• 92435-06-8 2-acetamido-N-(4-chlorophenyl)benzamide 
• 23746-76-1 5-chloro-2-phenylindole 
• 1266570-10-8 2-(4-chlorophenyl)-3,4-diphenylisoquinolin-1(2H)-one 
• 439930-62-8 ([μ,η2-(p-Cl-Ph)NC(O)(Ph)AlEt2])3 
• 350670-43-8 [Me2Al(η2-(p-ClC6H4)NC(Ph)C(H)C(Ph)N(p-ClC6H4))] 
• 21010-42-4 N-(2-Chlor-aethyl)-N-(4-chlor-phenyl)-benzamid 
• 71709-30-3 N,N'-di-p-chlorophenylbenzamidine 

Relevant articles and documents

Approach toward the understanding of coupling mechanism for EDC reagent in solvent-free mechanosynthesis

A unique approach in mechanosynthesis, joining solid-state NMR spectroscopy, X-ray crystallography, and theoretical calculations, is employed for the first time to study the mechanism of the formation of the C- N amide bond using EDC?HCl as a coupling reagent. It has been proved that EDC?HCl, which in the crystal lattice exists exclusively in the cyclic form (X-ray data), easily undergoes transformation to a pseudocyclic stable intermediate in reaction with carboxylic acid forming a low-melt phase (differential scanning calorimetry, solid-state NMR). The obtained intermediate is reactive and can be further used for synthesis of amides in reaction with appropriate amines.

In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C-N Bond Formation

We report an efficient Buchwald-Hartwig cross-coupling reaction in alcoholic solvent, in which a low catalyst loading showed excellent performance for coupling aryl halides (I, Br, and Cl) with a broad set of amines, amides, ureas, and carbamates under mild conditions. Mechanistically speaking, in a protic and polar medium, extremely bulky biarylphosphine ligands interact with the dimeric precatalyst [Pd(π-(R)-allyl)Cl]2 to form the corresponding cationic complexes [Pd(π-(R)-allyl)(L)]Cl in situ and spontaneously. The resulting precatalyst further evolves under basic conditions into the corresponding L-Pd(0) catalyst, which is commonly employed for cross-coupling reactions. This mechanistic study highlights the prominent role of alcoholic solvents for the formation of the active catalyst.

Visible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids

A visible-light-promoted and simple iron salt-catalyzed N-arylation was achieved efficiently under external photosensitizer-free conditions. Arylboronic acids and bench-stable dioxazolones were used for this cross-coupling reaction. This reaction features high reactivity, wide substrate scope, good functional group tolerance, simple operation procedure, and mild reaction conditions. Preliminary mechanistic investigations were conducted to support a radical pathway. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chemistry.

CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation

A magnetite-reduced graphene oxide-supported CuO nanocomposite (rGO/Fe3O4-CuO) was preparedviaa facile chemical method and characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Brunauer-Emmett-Teller (BET) analysis, vibrating-sample magnetometry (VSM), and thermogravimetric (TG) analysis. The catalytic activity of the rGO/Fe3O4-CuO nanocomposite was probed in the direct oxidative amidation reaction of methylarenes with free amines. Various aromatic and aliphatic amides were prepared efficiently at room temperature from cheap raw chemicals usingtert-butyl hydroperoxide (TBHP) as a “green” oxidant and low-toxicity TBAI in water. This method combines the oxidation of methylarenes and amide bond formation into a single operation. Moreover, the synthesized nanocomposites can be separated from the reaction mixtures using an external magnet and reused in six consecutive runs without a noticeable decrease in the catalytic activity.