53451-90-4

Basic information

• Product Name: 4-TRIFLUOROMETHYL DIPHENYL SULFIDE
• Synonyms: 4-TRIFLUOROMETHYL DIPHENYL SULFIDE;4-TRIFLUOROMETHYL DIPHENYL SULFIDE 97%MIN;phenyl(4-(trifluoromethyl)phenyl)sulfane;4-TRIFLUOROMETHYL DI
• CAS NO: 53451-90-4
• Molecular Formula: C₁₃H₉F₃S
• Molecular Weight: 254.27
• Mol File: 53451-90-4.mol
• Article Data: 61

Chemical Properties

• Melting Point: 36 °C
• Boiling Point: 314.8 °C at 760 mmHg
• Flash Point: 144.2 °C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0.000841mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 4-TRIFLUOROMETHYL DIPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TRIFLUOROMETHYL DIPHENYL SULFIDE(53451-90-4)
• EPA Substance Registry System: 4-TRIFLUOROMETHYL DIPHENYL SULFIDE(53451-90-4)

Safety Data

• Hazardous Substances Data: 53451-90-4(Hazardous Substances Data)

Usage

General Description

4-Trifluoromethyl diphenyl sulfide is a chemical compound with the molecular formula C14H9F3S. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. 4-TRIFLUOROMETHYL DIPHENYL SULFIDE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the fields of material science and organic synthesis due to its unique chemical properties, such as its ability to act as a ligand in catalytic reactions. 4-Trifluoromethyl diphenyl sulfide is also used as a reagent in the production of various organic compounds, making it an important intermediate in chemical manufacturing processes.

InChI:InChI=1/C13H9F3S/c14-13(15,16)10-6-8-12(9-7-10)17-11-4-2-1-3-5-11/h1-9H

Upstream product

• 108-86-1 bromobenzene 
• 455-13-0 4-Iodobenzotrifluoride 
• 139-66-2 diphenyl sulfide 
• 90141-51-8 1-(trifluoromethyl)-4-{[4-(trifluoromethyl)phenyl]sulfanyl}benzene 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 108-98-5 thiophenol 
• 98-80-6 phenylboronic acid 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 873-55-2 sodium benzenesulfonate 
• 882-33-7 diphenyldisulfane 
• 18715-45-2 4-trifluoromethylphenyl disulfide 
• 960-16-7 tributylphenylstannane 
• 85-44-9 phthalic anhydride 
• 825-83-2 4-trifluoromethylbenzenethiol 

Downstream Products

• 50986-93-1 1-(phenylsulfinyl)-4-(trifluoromethyl)benzene 
• 53451-93-7 1-(trifluoromethyl)-4-(phenylsulfonyl)benzene 

Relevant articles and documents

Palladium-catalysed thioetherification of aryl and alkenyl iodides using 1,3,5-trithiane as sulfur source

Thioetherification reaction of aryl iodides catalysed by palladium(II) complexes in the presence of 1,3,5-trithiane as sulphur source is reported. The paper presents the first homogeneous catalytic application of 1,3,5-trithiane in synthesis. Detailed optimization steps, the frames of the novel reaction are described, as well as the limitations and the substrate scope are also demonstrated. Moderate to good thioether yields were achieved in the presence of various substituted iodobenzenes and some alkenyl iodides, using palladium-xantphos catalyst system. Competitive reactions in the presence of mixed substrates were also performed and mechanistic considerations were assumed.

2-Sulfoximidoyl acetic acids from multicomponent petasis reactions and their use as building blocks in syntheses of sulfoximine benzodiazepine analogues

Upon application of a multicomponent Petasis reaction, a broad range of NH-sulfoximines and boronic acids react with glyoxalic acid to afford the corresponding 2-substituted acetic acids with N-bound sulfoximidoyl groups. The protocol features excellent y

Aryl thioether compound and preparation method thereof

The invention discloses an aryl thioether compound and a synthesis method thereof, wherein an aryl carboxylic acid and a mercaptan (phenol) are used as main raw materials, and a nickel catalyst is prepared. Under the action of the phosphine ligand and the additive, the aryl carboxylic acid and the thiol (phenol) react in an organic solvent, and after the reaction is finished, the corresponding aryl thioether is obtained. The method has the advantages of low cost, high yield, simple and convenient operation, no pollution and the like, and has potential industrial application prospects. The method provides a cheap and green way for preparation of aryl thioether compounds.