534595-51-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-4-Isopropylaminopiperidine is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the synthesis of a wide range of organic compounds, including drugs with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, 1-Boc-4-Isopropylaminopiperidine serves as a versatile building block for the synthesis of complex organic molecules. Its reactivity and functional groups make it a valuable component in the creation of new chemical entities with diverse properties and potential applications.
Used in Research and Development:
1-Boc-4-Isopropylaminopiperidine is also utilized in research and development settings, where it can be employed to explore new chemical reactions, investigate the properties of novel compounds, and develop innovative synthetic methodologies. Its unique structure and reactivity make it a valuable tool for advancing the understanding of organic chemistry and its applications in various fields.

InChI:InChI=1/C13H26N2O2/c1-10(2)14-11-6-8-15(9-7-11)12(16)17-13(3,4)5/h10-11,14H,6-9H2,1-5H3

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 67-64-1 acetone 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 75-31-0 isopropylamine 

Downstream Products

• 943223-57-2 C₂₀H₂₉F₃N₂O₄S 
• 1009633-60-6 C₂₁H₃₀ClN₃O₂ 
• 1137153-73-1 N-isopropyl-N-piperidin-4-yl-3-trifluoromethyl-benzenesulfonamide hydrochloride 
• 943224-30-4 C₂₀H₂₉F₃N₂O₃S 
• 1246249-90-0 2-(4-(4-(isopropylamino)piperidin-1-yl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1246249-80-8 N-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-N-isopropylacetamide 
• 1246249-83-1 N-(1-(4-formylphenyl)piperidin-4-yl)-N-isopropylacetamide 
• 1246249-81-9 tert-butyl 4-(N-isopropylacetamido)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Anti-inflammatory agents

Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). Also, disclosed are compositions comprising the novel compounds, as well as methods for their preparation.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.

Benzenesulfonamide Compounds and the Use Thereof

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined

New compounds

The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Discovery of a series of aminopiperidines as novel iNOS inhibitors

Nitric oxide (NO), a mediator of various physiological and pathophysiological processes, is synthesized by three isozymes of nitric oxide synthase (NOS). Potential candidate clinical drugs should be devoid of inhibitory activity against endothelial NOS (eNOS), since eNOS plays an important role in maintaining normal blood pressure and flow. A new series of aminopiperidines as potent inhibitors of iNOS were identified from a HTS lead. From this study, we identified compound 33 as a potent iNOS inhibitor, with >25-fold selectivity over eNOS and 16-fold selectivity over nNOS.

BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS

The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The inve

BENZENESULFONAMIDE COMPOUNDS AND THE USE THEREOF

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth

New indole derivatives as factor Xa inhibitors

The present invention relates to compounds of formula I, in which R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is indicated. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, in particular as pharmaceuticals for treating the foregoing conditions, and pharmaceutical preparations comprising them.