1-Boc-4-Isopropylaminopiperidine

Base Information

• Chemical Name: 1-Boc-4-Isopropylaminopiperidine
• CAS No.: 534595-51-2
• Molecular Formula: C13H26N2O2
• Molecular Weight: 242.362
• Hs Code.: 2933399090
• Mol file: 534595-51-2.mol

Synonyms:4-Isopropylaminopiperidine-1-carboxylicacid tert-butyl ester;1-Boc-4-Isopropylaminopiperidine;

Chemical Property of 1-Boc-4-Isopropylaminopiperidine

Chemical Property:

• Vapor Pressure: 0.000381mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 317.6 °C at 760 mmHg
• PKA: 10.19±0.20(Predicted)
• Flash Point: 145.9 °C
• PSA: 41.57000
• Density: 0.99 g/cm³
• LogP: 2.71270
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% 98%atom%13C ^*data from raw suppliers

tert-Butyl4-(Isopropylamino)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-Isopropylaminopiperidine

There total 3 articles about 1-Boc-4-Isopropylaminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + isopropylamine (75-31-0) → tert-butyl 4-(isopropylamino)piperidine-1-carboxylate (534595-51-2)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h;

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + acetone (67-64-1) → tert-butyl 4-(isopropylamino)piperidine-1-carboxylate (534595-51-2)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

→ tert-butyl 4-(isopropylamino)piperidine-1-carboxylate (534595-51-2)

Guidance literature:

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

isopropylamine

1-(tert-butoxycarbonyl)-4-aminopiperidine

acetone

Downstream raw materials:

C₂₀H₂₉F₃N₂O₃S

C₂₀H₂₉F₃N₂O₄S

C₂₁H₃₀ClN₃O₂

tert-butyl 4-(N-isopropylacetamido)piperidine-1-carboxylate