53460-57-4

Upstream product

• 645-54-5 2-phenylthioacetamide 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 17591-59-2 3,5-dibenzyl-4-amino-1,2,4-triazole 
• 14141-65-2 3,6-dibenzyl-1,2,4,5-tetrazine 
• 793-25-9 1,2-di(phenylacetyl)hydrazine 
• 103-82-2 phenylacetic acid 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its diazo ligand, metal complexes along with anticancer activity

Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.

Synthesis and antitumor activity of s-tetrazine derivatives

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.