793-25-9

Usage

Usage

Starting material in the synthesis of dyes and pigments

Physical state

Pale yellow crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Health classification

Probable human carcinogen

Regulatory status

Use restricted in some regions due to potential health risks

Safety precautions

Handle with care and follow all safety guidelines to prevent exposure and health hazards

Upstream product

• 123-76-2 levulinic acid 
• 937-39-3 2-phenylacetylhydrazine 
• 134-81-6 benzil 
• 103-80-0 phenylacetyl chloride 
• 66407-91-8 Ethyl α-diphenylphosphinylphenylacetate 
• 6996-92-5 benzeneseleninic acid 
• 7647-01-0 hydrogenchloride 
• 53460-57-4 dihydro-1,2,4,5-tetrazine-3,6-dibenzyl 
• 110-89-4 piperidine 
• 141-97-9 ethyl acetoacetate 
• 103-82-2 phenylacetic acid 
• 67-66-3 chloroform 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 112363-47-0 N,N'-dimethyl-N,N'-di(phenylacetyl)hydrazine 
• 16537-09-0 t-butyl phenylacetate 
• 138211-99-1 1,2-dimethyl-3-benzyl-4-phenyl-5-pyrazolone 
• 132401-08-2 N,N'-dimethyl-threo-2,3-diphenylsuccinimide 
• 140-29-4 phenylacetonitrile 
• 93020-51-0 2,5-dibenzyl-[1,3,4]thiadiazole 
• 58022-66-5 2,5-dibenzyl-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

A simple and efficient oxidation of hydrazides to N,N'-diacylhydrazines using Oxone in an aqueous medium

Substituted aromatic hydrazides have been oxidised to N,N'- diacylhydrazines in high yields using Oxone in an aqueous medium at room temperature.

Syntheses of hydrazides by a direct condensation reaction using phosphorous acid-iodine as a reagent

Aliphatic and aromatic hydrazides have been prepared in high to moderate yields by a direct condensation reaction of aliphatic or aromatic carboxylic acids with hydrazine or phenylhydrazine using phosphorous acid-iodine as reagent and pyridine as base and solvent. With aliphatic carboxylic acids, we obtained good results heating at 80-90°, for 5-6 hours, but with aromatic carboxylic acids are necessary 140-150°, for the same period of time.

Some hypervalent iodine(III) mediated solid-state transformations

Some known hypervalent iodine(III) mediated reactions, viz (i) dimerization of acid hydrazides 1a-i, (ii) α-tosyloxylation of acetophenones 3a-f, and (iii) α-hydroxylation of acetophenones 3c,d,f have been effected in solid-state.

Oxidation of Hydrazides Using Sodium Perborate: Formation of N,N′-Diacylhydrazines

Substituted aromatic hydrazides react very smoothly with sodium perborate in glacial acetic acid at room temperature to give N,N′-diacylhydrazines in excellent yields and purity.

Iodobenzene Diacetate Mediated Synthesis of N,N'-Diacylhydrazines: A Convenient Synthesis of 1,3,4-Oxadiazoles

Iodobenzene diacetate (IBD) has been found to be an excellent reagent for the oxidation of a variety of acid hydrazides to N,N'-diacylhydrazines which undergo ready cyclization to yield the corresponding oxadiazoles.

Hypervalent iodine oxidation of acid hydrazides: A new synthesis of N,N'-diacylhydrazines

Hypervalent iodine oxidation of p-substituted benzohydrazides (1a-h), phenylacetohydrazide (1i) and heterocyclic acid hydrazides (1j-l) using one equivalent of iodobenzene diacetate in dry dichloromethane or acetonitrile leads to dimerization thereby providing a new and facile method for the synthesis of N,N-diacylhydrazines 2.

OXIDATION OF HYDRAZINES WITH CARBON TETRACHLORIDE

Some hydrazines, especially 1,2-dialkylhydrazines are oxidized to the corresponding diazenes (azo compounds) by carbon tetrachloride presumably via nucleophilic attack by nitrogen on chlorine.Monacylhydrazines are converted to the corresponding diacylhydrazines.

A new method for synthesis of 1H-pyrazol-3(2H)-ones

A new preparative method is reported for the synthesis of 4,5-disubstituted 1,2-dimethyl-1H-pyrazol-3(2H)-ones 5a-e,g-k from N,N-diacyl-N,N'-dimethylhydrazines 1a-e,g,h,j,k. The method is based on the intramolecular formation of thc 4,5-bond in the pyrazo

Oxidation of Hydrazines with Benzeneseleninic Acid and Anhydride

Benzeneseleninic acid (1) and anhydride (2) oxidize hydrazine or 1,2-disubstituted derivatives to corresponding diazenes.Hydrazides afford selenoesters 4, N,N'-diacyl- or diaroylhydrazines 5, and carboxylic acids.Benzeneselenenic acid (7) is a required intermediate in selenoester formation and may be generated independently by the reaction of triphenylphosphine with 1.Selenoesters are efficiently prepared by the slow addition of a mixture of the hydrazide and triphenylphosphine to 1 in dichloromethane solution.Polar solvents are unsuitable.Inverse addition provides compounds 5 as major products.Oxidation of hydrazides of structure HO-(CH2)nCONHNH2 gives the corresponding selenoesters 14 and acids 16 when n=11 or 14 lactones 17 and 18 when n=4 or 3.Arylhydrazines react with 1 or 2 to furnish arenes 23 and aryl phenyl selenides 24.