53460-78-9

Usage

Uses

Used in Organic Synthesis:
Acetamide, N-[2-(acetyloxy)-3-chloropropyl]is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions. The acetyloxy and chloropropyl groups enhance the compound's reactivity, making it suitable for the formation of new chemical entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Acetamide, N-[2-(acetyloxy)-3-chloropropyl]is utilized in the preparation of various pharmaceuticals. Its unique structure allows it to be a key intermediate in the synthesis of drug molecules, contributing to the development of new therapeutic agents.
Used in Agrochemicals:
Acetamide, N-[2-(acetyloxy)-3-chloropropyl]is also used in the agrochemical sector for the synthesis of agrochemicals. Its properties make it a valuable component in the creation of pesticides, herbicides, and other agricultural chemicals that are essential for crop protection and yield enhancement.
Used in Fine Chemicals:
Acetamide, N-[2-(acetyloxy)-3-chloropropyl]finds application in the production of fine chemicals, which are high-purity chemicals used in various specialized applications. The acetyloxy and chloropropyl groups in Acetamide, N-[2-(acetyloxy)-3-chloropropyl]provide the necessary functional groups for the synthesis of these high-value chemicals.

Upstream product

• 108-24-7 acetic anhydride 
• 62037-46-1 rac-1-amino-3-chloro-2-propanol hydrochloride 
• 24573-30-6 3-chloro-2-hydroxy-1-propyl acetate 
• 75-05-8 acetonitrile 

Relevant academic research and scientific papers

Diol-Ritter Reaction: Regio- And Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation

The well-known epoxide-Ritter reaction generally affords oxazolines with poor to average regioselectivity. Herein, a mechanism-based study of the less known diol-Ritter reaction has provided a highly regioselective procedure for the synthesis of 1-vic-amido-2-esters from either terminal epoxides or 1,2-diols via Lewis acid-catalyzed monoesterification. When treated with a stoichiometric Lewis acid catalyst (BF3), these diol monoesters form dioxonium cation intermediates that are ring-opened with nitrile nucleophiles to form nitrilium intermediates, which undergo rapid and irreversible hydration to give the desired amidoesters. Diester byproduct formation is irreversible and appears to occur through disproportionation of diol monoester. With chiral epoxide starting materials, the formation of amidoester occurs with retention of configuration and no apparent erosion of optical purity as determined by single-crystal X-ray analyses and chiral chromatography, respectively. The direct access to chiral vic-amidoesters is especially practical with regard to the synthesis of antibacterial oxazolidinone analogues of the Zyvox antimicrobial family.

Phthalamide compounds

The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN??(VIIIA) and processes for production of pharmacologically useful oxazolidinones.

Process to produce oxazolidinones

The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2-CH2-C*H(OH)-CH2-NH-CO-RN(VIIIA) and processes for production of pharmacologically useful oxazolidinones.