24573-30-6

Basic information

• Product Name: Acetic acid 2-hydroxy-3-chloropropyl ester
• Synonyms: 1-Acetoxy-3-chloro-2-propanol;3-Chloro-1,2-propanediol 1-acetate;Acetic acid 2-hydroxy-3-chloropropyl ester;Acetic acid 2-hydroxy-3-chloro-propyl ester;U-25792;3-chloro-2-hydroxypropyl acetate;1,2-Propanediol, 3-chloro-, 1-acetate
• CAS NO: 24573-30-6
• Molecular Formula: C₅H₉ClO₃
• Molecular Weight: 152.58
• Mol File: 24573-30-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231.1°C at 760 mmHg
• Flash Point: 93.6°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.45
• PKA: 13.00±0.20(Predicted)
• CAS DataBase Reference: Acetic acid 2-hydroxy-3-chloropropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 2-hydroxy-3-chloropropyl ester(24573-30-6)
• EPA Substance Registry System: Acetic acid 2-hydroxy-3-chloropropyl ester(24573-30-6)

Safety Data

• Hazardous Substances Data: 24573-30-6(Hazardous Substances Data)

Usage

General Description

Acetic acid 2-hydroxy-3-chloropropyl ester, also known as glycidol acetate, is an organic compound commonly used as a stabilizer and inhibitor in the production of flavoring agents, fragrances, and pharmaceuticals. It is a colorless liquid with a sweet odor, and it is highly flammable. This chemical is designated as a potential occupational carcinogen and poses a health risk due to its potential to cause respiratory irritation and skin sensitization. Due to its hazardous properties, precautions should be taken when handling acetic acid 2-hydroxy-3-chloropropyl ester, and proper safety measures should be put in place to avoid exposure.

InChI:InChI=1/C5H9ClO3/c1-4(7)9-3-5(8)2-6/h5,8H,2-3H2,1H3

Upstream product

• 64-19-7 acetic acid 
• 56-81-5 glycerol 
• 106-89-8 epichlorohydrin 
• 71-36-3 butan-1-ol 
• 108-22-5 Isopropenyl acetate 
• 96-24-2 3-monochloro-1,2-propanediol 
• 108-05-4 vinyl acetate 

Downstream Products

• 7748-36-9 oxetan-3-ol 
• 53460-78-9 rac-1-acetamido-2-acetoxy-3-chloropropane 
• 869-50-1 1,2-diacetoxy-3-chloro-propane 
• 40235-68-5 3-chloro-2-oxopropyl acetate 
• 93647-11-1 2-Methoxy-1-acetoxy-3-phenoxy-propan 
• 85328-35-4 3-Chloro-2-(1-ethoxyethoxy)-1-propyl acetate 
• 6387-89-9 glycidyl acetate 
• 63715-95-7 1-O-acetyl-3-(phenoxy)propane-1,2-diol 

Relevant articles and documents

CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN

The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

Distannoxane-catalyzed selective acetylation of 3-chloropropane-1,2- diol: A convenient synthesis of enantiopure epichlorohydrin

A distannoxane catalyst effects exclusive acetylation of the primary alcohol of 3-chloropropane-1,2-diol. This reaction provides a convenient access to enantiopure epichlorohydrin.