24573-30-6

Usage

Uses

Used in Flavoring and Fragrance Industry:
Acetic acid 2-hydroxy-3-chloropropyl ester is used as a stabilizer and inhibitor for enhancing the quality and safety of flavoring agents and fragrances. Its application helps to prevent the degradation of these compounds, ensuring their longevity and effectiveness in various products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, acetic acid 2-hydroxy-3-chloropropyl ester serves a similar purpose as a stabilizer and inhibitor. It is utilized to maintain the stability and potency of active pharmaceutical ingredients, thereby ensuring the safety and efficacy of medications.
Due to the potential health risks associated with acetic acid 2-hydroxy-3-chloropropyl ester, it is crucial to implement proper safety measures during its production, handling, and use. This includes minimizing exposure through the use of personal protective equipment, proper ventilation, and adherence to safety guidelines and regulations.

InChI:InChI=1/C5H9ClO3/c1-4(7)9-3-5(8)2-6/h5,8H,2-3H2,1H3

Upstream product

• 108-05-4 vinyl acetate 
• 96-24-2 3-monochloro-1,2-propanediol 
• 108-22-5 Isopropenyl acetate 
• 64-19-7 acetic acid 
• 106-89-8 epichlorohydrin 
• 71-36-3 butan-1-ol 
• 56-81-5 glycerol 

Downstream Products

• 63715-95-7 1-O-acetyl-3-(phenoxy)propane-1,2-diol 
• 6387-89-9 glycidyl acetate 
• 85328-35-4 3-Chloro-2-(1-ethoxyethoxy)-1-propyl acetate 
• 93647-11-1 2-Methoxy-1-acetoxy-3-phenoxy-propan 
• 7748-36-9 oxetan-3-ol 
• 53460-78-9 rac-1-acetamido-2-acetoxy-3-chloropropane 
• 869-50-1 1,2-diacetoxy-3-chloro-propane 
• 40235-68-5 3-chloro-2-oxopropyl acetate 

Relevant academic research and scientific papers

CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN

The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

The solvent effects in the reactions of carboxylic acids with oxiranes. 1. Kinetics of the reaction of acetic acid with epichlorohydrin in butan-1-ol

Kinetics of the reaction of acetic acid with epichlorohydrin in the presence of chromium(III) acetate in butan-1-ol solution have been studied. The partial reaction orders with respect to reagents were found. The reactions were of first-order with respect to both epichlorohydrin and catalyst and zeroth order with respect to acetic acid. A kinetic model for the overall process has been proposed. The reaction constants have been calculated along with the activation parameters. The effect of dilution on the rate of addition is discussed. In the equimolar mixture of acetic acid and epichlorohydrin the apparent rate constant of the addition k1 initially decreases to increase again at the concentration of butan-1-ol exceeding 3 M.

Distannoxane-catalyzed selective acetylation of 3-chloropropane-1,2- diol: A convenient synthesis of enantiopure epichlorohydrin

A distannoxane catalyst effects exclusive acetylation of the primary alcohol of 3-chloropropane-1,2-diol. This reaction provides a convenient access to enantiopure epichlorohydrin.