53460-88-1Relevant academic research and scientific papers
Synthesis of 3-Formylbenzenesulfonyl Chloride Derivatives
Bao, Xuefei,Liu, Ziao,Liang, Xinjie,Song, Dake,Shi, Tao,Zhao, Xuan,Bao, Changshun,Chen, Guoliang
, p. 3165 - 3170 (2017/07/12)
A synthetic route to 3-formylbenzenesulfonyl chloride derivatives from the corresponding benzaldehydes has been developed. The key step in this procedure is the conversion of aldehyde bisulfite adducts to target compounds via a two-stage reaction in the presence of Na 2 SO 4. A series of 3-formylbenzenesulfonyl chloride derivatives were prepared by this method and identified by chemical derivatization method.
The Development of an Effective Synthetic Route of Belinostat
Bao, Xuefei,Song, Dake,Qiao, Xuejun,Zhao, Xuan,Chen, Guoliang
, p. 1482 - 1488 (2016/08/30)
A practical synthetic route of belinostat is reported. Belinostat was obtained via a five-step process starting from benzaldehyde and including addition reaction with sodium bisulfite, sulfochlorination with chlorosulfonic acid, sulfonamidation with aniline, Knoevenagel condensation, and the final amidation with hydroxylamine. Key to the strategy is the preparation of 3-formylbenzenesulfonyl chloride using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and acceptable overall yield. The scale-up experiment was carried out to provide 169 g of belinostat with 99.6% purity in 33% total yield.
