534601-72-4Relevant academic research and scientific papers
An efficient one-pot construction of substituted pyrimidinones
Lu, Yuelie,Xiang, Tingjian,Bartberger, Michael D.,Bernard, Charles,Bostick, Tracy,Huang, Liang,Liu, Longbin,Siegmund, Aaron,Sukay, Gregory,Guo, Gary,Elipe, Maria Silva,Tormos, Wanda,Dominguez, Celia,Koch, Kevin,Burgess, Laurence E.,Basil, Thomas C.,Ibrahim, Prabha,Hummel, Conrad
, p. 11714 - 11723 (2006)
A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hy
Substituted indolizine-like compounds and methods of use
-
, (2008/06/13)
Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
