53486-54-7Relevant academic research and scientific papers
Simultaneous determination of enantiomerization and hydrolysis kinetic parameters of chiral N-alkylbenzothiadiazine derivatives
Carrozzo, Marina M.,Cannazza, Giuseppe,Battisti, Umberto,Braghiroli, Daniela,Parenti, Carlo
experimental part, p. 389 - 397 (2010/08/06)
On-column stopped flow multidimensional HPLC (sfMDHPLC) and dynamic high-performance liquid chromatography were applied to investigate the influence of alkyl substituents at the sulfonamidic and amino moieties of benzothiadiazine 1,1-dioxide derivatives o
A novel class of allosteric modulators of AMPA/Kainate receptors
Cannazza, Giuseppe,Jozwiak, Krzysztof,Parenti, Carlo,Braghiroli, Daniela,Carrozzo, Marina M.,Puia, Giulia,Losi, Gabriele,Baraldi, Mario,Lindner, Wolfgang,Wainer, Irving W.
supporting information; experimental part, p. 1254 - 1257 (2009/09/04)
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
